ArticleNutrients2023
Body Mass Index Measured Repeatedly over 42 Years as a Risk Factor for Ischemic Stroke: The HUNT Study.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Association between the newly introduced Diet Index for Gut Microbiota (DI-GM) and stroke prevalence: potential indirect associations via phenotypic age and body mass index (BMI).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Association of body mass index trajectories with incidence of stroke among elderly Chinese adults: a 10-year cohort study.Frontiers in nutrition · 2026Article
- Improving cardiometabolic multimorbidity prediction with a composite obesity-TyG index: a study of middle-aged and older adults in CHARLS.Archives of public health = Archives belges de sante publique · 2025Article
- Observational
- Severity and stroke type according to waist-Hip ratio, body mass index and waist circumference.Journal of neural transmission (Vienna, Austria : 1996) · 2025Observational
- Triglyceride-glucose index combined with estimated pulse wave velocity improves stroke risk stratification in the CHARLS cohort.Scientific reports · 2025Article
- Multimodal machine learning-based marker enables the link between obesity-related indices and future stroke: a prospective cohort study.EClinicalMedicine · 2025Article
- Effect of metabolic disorders on reactive gliosis and glial scarring at the early subacute phase of stroke in a mouse model of diabetes and obesity.IBRO neuroscience reports · 2025Article
- Association Between Estimated Glucose Disposal Rate and Stroke in Middle-Aged and Older Chinese Adults: A Nationwide Prospective Cohort Study.Journal of the American Heart Association · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Synergistic effects of triglyceride-glucose index and body mass index combined with depression in predicting stroke events: a study based on two national cohorts.Frontiers in nutrition · 2025Article
- "Obesity, metabolic abnormalities and low-grade inflammation: differencial associations with subclinical atherosclerosis".Frontiers in cardiovascular medicine · 2025Article
- Joint association of estimated glucose disposal rate and body mass index with new-onset stroke.Frontiers in neurology · 2025Article
- Association between serum albumin-to-globulin ratio and subtypes of cerebral atherosclerotic stenosis in acute ischemic stroke.Frontiers in neurology · 2025Article
- Joint Modifiable Risk Factor Control and Incident Stroke in Hypertensive Patients.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Atherogenic index of plasma and obesity-related risk of stroke in middle-aged and older Chinese adults: a national prospective cohort study.Diabetology & metabolic syndrome · 2024Article
- Leveraging multivariate analysis and adjusted mutual information to improve stroke prediction and interpretability.Neurosciences (Riyadh, Saudi Arabia) · 2024Article
- Article
- Review
- Interacting and joint effects of triglyceride-glucose index (TyG) and body mass index on stroke risk and the mediating role of TyG in middle-aged and older Chinese adults: a nationwide prospective cohort study.Cardiovascular diabetology · 2024Article
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8 authors.
Funding
Abstract
backgroundHigher BMI in middle age is associated with ischemic stroke, but little is known about BMI over adulthood, and the risk for ischemic stroke as most studies relied on a single measurement of BMI.
methodsBMI was measured four times over a period of 42 years. We calculated average BMI values and group-based trajectory models and related these to the prospective risk of ischemic stroke after the last examination in Cox models with a follow-up time of 12 years.
resultsA total of 14,139 participants, with a mean age of 65.2 years and 55.4% women, had information on BMI from all four examinations, and we observed 856 ischemic strokes. People with overweight and obesity over adulthood had a higher risk for ischemic stroke with a multivariable-adjusted hazard ratio of 1.29 (95% CI 1.11-1.48) and 1.27 (95% CI 0.96-1.67), respectively, when compared to normal weight participants. Excess weight tended to have stronger effects earlier than later in life. A trajectory of developing obesity throughout life was associated with higher risk than other trajectories.
conclusionsHigh average BMI, especially at an early age, is a risk factor for ischemic stroke. Early weight control and long-term weight reduction for those with high BMI may decrease the later occurrence of ischemic stroke.
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