Evidence map›Paper›PMID 36904179›Full record

Trial reportNutrients2023

Tolerance Induction in Cow's Milk Allergic Children by Heated Cow's Milk Protein: The iAGE Follow-Up Study.

Frank E van Boven, Nicolette J T Arends, Aline B Sprikkelman, Joyce A M Emons, Astrid I Hendriks, Marloes van Splunter, Marco W J Schreurs, Severina Terlouw, Roy Gerth van Wijk, Harry J Wichers and 4 more

Full text readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Frank E van BovenDepartment of Internal Medicine, Section of Allergology & Clinical Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.
Nicolette J T ArendsDepertment of Peadiatric Allergology, Sophia Children Hospital, Erasmus MC, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.
Aline B SprikkelmanDepartment of Peadiatric Pulmonology & Allergology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Joyce A M EmonsDepertment of Peadiatric Allergology, Sophia Children Hospital, Erasmus MC, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.
Astrid I HendriksDepertment of Peadiatric Allergology, Sophia Children Hospital, Erasmus MC, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.
Marloes van SplunterCell Biology & Immunology, Wageningen University & Research, 6708 PB Wageningen, The Netherlands.
Marco W J SchreursDepartment of Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.
Severina TerlouwDepartment of Internal Medicine, Section of Allergology & Clinical Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-1724-3626
Roy Gerth van WijkDepartment of Internal Medicine, Section of Allergology & Clinical Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.
Harry J WichersFood & Biobased Research, Wageningen University & Research, 6700 AA Wageningen, The Netherlands.ORCID 0000-0002-8030-7090
Huub F J SavelkoulCell Biology & Immunology, Wageningen University & Research, 6708 PB Wageningen, The Netherlands.ORCID 0000-0001-6236-7092
R J Joost van NeervenCell Biology & Immunology, Wageningen University & Research, 6708 PB Wageningen, The Netherlands.ORCID 0000-0002-3991-5297
Kasper A HettingaDairy Science and Technology, Food Quality and Design Group, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands.ORCID 0000-0002-9017-4447
Nicolette W de JongDepartment of Internal Medicine, Section of Allergology & Clinical Immunology, Erasmus MC, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-7216-0906

Funding

Dutch Research Council 14536
6 · The paper itself

Abstract

Accelerating the induction of tolerance to cow's milk (CM) reduces the burden of cow's milk allergy (CMA). In this randomised controlled intervention study, we aimed to investigate the tolerance induction of a novel heated cow milk protein, the iAGE product, in 18 children with CMA (diagnosed by a paedriatric allergist). Children who tolerated the iAGE product were included. The treatment group (TG:

Indexed as

MilkMilk HypersensitivityMilk ProteinsAllergensAnimalsCattleFollow-Up StudiesHumansImmune ToleranceImmunoglobulin EInfantAllergensImmunoglobulin EMilk Proteinscow’s milkfood allergyheated proteinrandomized controlled trialsafetytolerance

Identifiers

PMID36904179
PMCPMC10005260

What OpenQuestion holds

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reference markers read1
measurements read28
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.