Evidence map›Paper›PMID 36904122›Full record

ReviewNutrients2023

The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases.

Tsubasa Tsutsumi, Dan Nakano, Ryuki Hashida, Tomoya Sano, Machiko Kawaguchi, Keisuke Amano, Takumi Kawaguchi

Full text readReview
In one paragraph

Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  8. World journal of hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tsubasa TsutsumiDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.ORCID 0000-0001-6571-9874
Dan NakanoDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Ryuki HashidaDepartment of Orthopedics, School of Medicine, Kurume University, Kurume 830-0011, Japan.ORCID 0000-0002-2459-9949
Tomoya SanoDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.ORCID 0000-0002-3229-3149
Machiko KawaguchiDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Keisuke AmanoDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Takumi KawaguchiDivision of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.ORCID 0000-0002-7064-4325

Funding

Japan Agency for Medical Research and Development JP22fk0210090
6 · The paper itself

Abstract

Fatty liver is known to be associated with extra-hepatic diseases including atherosclerotic cardiovascular disease and extra-hepatic cancers, which affect the prognosis and quality of life of the patients. The inter-organ crosstalk is mediated by metabolic abnormalities such as insulin resistance and visceral adiposity. Recently, metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed as a new definition for fatty liver. MAFLD is characterized by the inclusion criteria of metabolic abnormality. Therefore, MAFLD is expected to identify patients at high risk of extra-hepatic complications. In this review, we focus on the relationships between MAFLD and multi-organ diseases. We also describe the pathogenic mechanisms of the inter-organ crosstalk.

Indexed as

AtherosclerosisNon-alcoholic Fatty Liver DiseaseCell Physiological PhenomenaCross ReactionsHumansQuality of Lifeatherosclerotic cardiovascular diseasechronic kidney diseasechronic obstructive pulmonary diseasecognitive impairmentextrahepatic carcinomaextrahepatic diseasesmetabolic-associated fatty liver diseasemulti-organ diseasessarcopeniathyroid disease

Identifiers

PMID36904122
PMCPMC10005526

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measurements read41
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.