Evidence map›Paper›PMID 36904073›Full record

ArticleNutrients2023

Enhanced Nutraceutical Properties of Extra Virgin Olive Oil Extract by Olive Leaf Enrichment.

Doretta Cuffaro, Simone Bertini, Marco Macchia, Maria Digiacomo

Open access · goldFull text read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

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  9. In-Depth Analysis ofBiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Doretta CuffaroDepartment of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0002-8842-542X
Simone BertiniDepartment of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0001-8832-8075
Marco MacchiaDepartment of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy.
Maria DigiacomoDepartment of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0003-0653-6642
University of Pisa · IT

Funding

Ministry of University and Research (MUR) PON 2014-2020 "Research and Innovation" resources - Green/Innovation Action - DM MUR 1062/2021University of Pisa Project no. PRA_2020-2021
6 · The paper itself

Abstract

(1) Background: Nowadays, the health-promoting properties of extra virgin olive oil (EVOO), including the antioxidant and anti-inflammatory actions, are well recognized and mainly attributed to the different polyphenols, such as oleocanthal and oleacein. In EVOO production, olive leaves represent a high value by-product, showing a wide spectrum of beneficial effects due to the presence of polyphenols, especially oleuropein. Here we report the study of olive leaf extract (OLE)-enriched EVOO extracts, obtained by adding different percentages of OLE to EVOO in order to ameliorate their nutraceutical activities. (2) Methods: The polyphenolic content of the EVOO/OLE extracts was analyzed by HPLC and the Folin-Ciocalteau assay. For further biological testing, an 8% OLE-enriched EVOO extract was chosen. Therefore, antioxidant effects were evaluated by three different methods (DPPH, ABTS, and FRAP), and the anti-inflammatory properties were assessed in terms of cyclooxygenase activity inhibition. (3) Results: The antioxidant and anti-inflammatory profiles of the new EVOO/OLE extract are significantly improved compared to those of EVOO extract; (4) Conclusions: The combination of OLE and EVOO extract can lead to an extract enriched in terms of bioactive polyphenols and endowed with better biological properties than the singular EVOO extract. Therefore, it may represent a new complement in the nutraceutical field.

Indexed as

Anti-Inflammatory AgentsDietary SupplementsOlive OilPlant OilsAntioxidantsPlant ExtractsPlant LeavesPolyphenolsAnti-Inflammatory AgentsAntioxidantsOlive OilPlant ExtractsPlant OilsPolyphenolsanti-inflammatory activityantioxidant activityEVOO enrichmentextra virgin olive oilolive leavespolyphenols

Identifiers

PMID36904073
PMCPMC10005073
OpenAlexW4321498380

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read117
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.