Evidence map›Paper›PMID 36903679›Full record

ArticleNanomaterials (Basel, Switzerland)2023

Cluster-Assembled Zirconia Substrates Accelerate the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.

Sara Castiglioni, Laura Locatelli, Alessandra Cazzaniga, Francesca Maria Orecchio, Tommaso Santaniello, Claudio Piazzoni, Lionel Bureau, Francesca Borghi, Paolo Milani, Jeanette A Maier

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In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara CastiglioniDepartment of Biomedical and Clinical Sciences, Università di Milano, 20157 Milano, Italy.ORCID 0000-0002-8785-9891
Laura LocatelliDepartment of Biomedical and Clinical Sciences, Università di Milano, 20157 Milano, Italy.ORCID 0000-0002-4568-7825
Alessandra CazzanigaDepartment of Biomedical and Clinical Sciences, Università di Milano, 20157 Milano, Italy.ORCID 0000-0001-7153-2256
Francesca Maria OrecchioDepartment of Physics and Interdisciplinary Centre for Nanostructured Materials and Interfaces (C.I.Ma.I.Na.[M1]), University of Milan, Via Giovanni Celoria, 16, 20133 Milan, Italy.ORCID 0000-0002-6508-7472
Tommaso SantanielloDepartment of Physics and Interdisciplinary Centre for Nanostructured Materials and Interfaces (C.I.Ma.I.Na.[M1]), University of Milan, Via Giovanni Celoria, 16, 20133 Milan, Italy.
Claudio PiazzoniDepartment of Physics and Interdisciplinary Centre for Nanostructured Materials and Interfaces (C.I.Ma.I.Na.[M1]), University of Milan, Via Giovanni Celoria, 16, 20133 Milan, Italy.ORCID 0000-0002-8052-8053
Lionel BureauLaboratoire Interdisciplinaire de Physique (LIPhy), Université Grenoble Alpes, CNRS, F-38000 Grenoble, France.
Francesca BorghiDepartment of Physics and Interdisciplinary Centre for Nanostructured Materials and Interfaces (C.I.Ma.I.Na.[M1]), University of Milan, Via Giovanni Celoria, 16, 20133 Milan, Italy.ORCID 0000-0001-6980-4910
Paolo MilaniDepartment of Physics and Interdisciplinary Centre for Nanostructured Materials and Interfaces (C.I.Ma.I.Na.[M1]), University of Milan, Via Giovanni Celoria, 16, 20133 Milan, Italy.ORCID 0000-0001-9325-4963
Jeanette A MaierDepartment of Biomedical and Clinical Sciences, Università di Milano, 20157 Milano, Italy.

Funding

University of Milan Bando SEED 2019
6 · The paper itself

Abstract

Due to their high mechanical strength and good biocompatibility, nanostructured zirconia surfaces (ns-ZrOx) are widely used for bio-applications. Through supersonic cluster beam deposition, we produced ZrOx films with controllable roughness at the nanoscale, mimicking the morphological and topographical properties of the extracellular matrix. We show that a 20 nm ns-ZrOx surface accelerates the osteogenic differentiation of human bone marrow-derived MSCs (bMSCs) by increasing the deposition of calcium in the extracellular matrix and upregulating some osteogenic differentiation markers. bMSCs seeded on 20 nm ns-ZrOx show randomly oriented actin fibers, changes in nuclear morphology, and a reduction in mitochondrial transmembrane potential when compared to the cells cultured on flat zirconia (flat-ZrO

Indexed as

bMSCnanostructured zirconia surfacesosteogenic differentiation

Identifiers

PMID36903679
PMCPMC10005756

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.