Evidence map›Paper›PMID 36903639›Full record

ArticleMolecules (Basel, Switzerland)2023

Recombinant Domain of Flagellin Promotes In Vitro a Chemotactic Inflammatory Profile in Human Immune Cells Independently of a Dendritic Cell Phenotype.

Roxana González-Stegmaier, Adam Aguirre, Constanza Cárcamo, Patricia Aguila-Torres, Franz Villarroel-Espíndola

Open access · goldFull text read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Roxana González-StegmaierTranslational Medicine Laboratory, Instituto Oncológico Fundación Arturo López Pérez, Santiago 8320000, Chile.ORCID 0000-0002-6345-7054
Adam AguirreTranslational Medicine Laboratory, Instituto Oncológico Fundación Arturo López Pérez, Santiago 8320000, Chile.
Constanza CárcamoTranslational Medicine Laboratory, Instituto Oncológico Fundación Arturo López Pérez, Santiago 8320000, Chile.
Patricia Aguila-TorresLaboratorio de Microbiología Molecular, Escuela de Tecnología Médica, Universidad Austral de Chile, Puerto Montt 5480000, Chile.ORCID 0000-0002-3906-5691
Franz Villarroel-EspíndolaTranslational Medicine Laboratory, Instituto Oncológico Fundación Arturo López Pérez, Santiago 8320000, Chile.ORCID 0000-0003-0080-2444
Fundación Arturo López Pérez · CLAustral University of Chile · CL

Funding

FONDECYT 1221415
6 · The paper itself

Abstract

Flagellin is the major component of the flagellum in gram-positive and -negative bacteria and is also the ligand for the Toll-like receptor 5 (TLR5). The activation of TLR5 promotes the expression of proinflammatory cytokines and chemokines and the subsequent activation of T cells. This study evaluated a recombinant domain from the amino-terminus D1 domain (rND1) of flagellin from

Indexed as

Chemotaxis, LeukocyteFlagellinChemokinesCytokinesDendritic CellsHumansLeukocytes, MononuclearPhenotyperho GTP-Binding ProteinsToll-Like Receptor 5ChemokinesCytokinesFlagellinrho GTP-Binding ProteinsRND1 protein, humanToll-Like Receptor 5cytokinesflagellinimmunomodulationPAMPsTLR5

Identifiers

PMID36903639
PMCPMC10005431
OpenAlexW4323315413

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read73
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.