Evidence map›Paper›PMID 36903631›Full record

ArticleMolecules (Basel, Switzerland)2023

Infrared Spectroscopy as a Potential Diagnostic Tool for Medulloblastoma.

Kornelia Łach, Aneta Kowal, Marta Perek-Polnik, Paweł Jakubczyk, Christopher J Arthur, Wioletta Bal, Monika Drogosiewicz, Bożenna Dembowska-Bagińska, Wiesława Grajkowska, Józef Cebulski and 1 more

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In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kornelia ŁachDepartment of Pediatrics, Institute of Medical Sciences, University of Rzeszow, 35-310 Rzeszow, Poland.ORCID 0000-0001-8339-1374
Aneta KowalDoctoral School, Institute of Medical Sciences, University of Rzeszow, 35-310 Rzeszow, Poland.
Marta Perek-PolnikDepartment of Oncology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Paweł JakubczykFaculty of Mathematics and Natural Sciences, University of Rzeszow, 35-310 Rzeszow, Poland.ORCID 0000-0002-5353-7915
Christopher J ArthurSchool of Chemistry, University of Bristol, Bristol BS8 1TS, UK.ORCID 0000-0001-7577-8472
Wioletta BalDepartment of Pediatrics, Institute of Medical Sciences, University of Rzeszow, 35-310 Rzeszow, Poland.
Monika DrogosiewiczDepartment of Oncology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Bożenna Dembowska-BagińskaDepartment of Oncology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Wiesława GrajkowskaDepartment of Pathology, The Children's Memorial Health Institute, University of Warsaw, 04-730 Warsaw, Poland.ORCID 0000-0001-8318-5781
Józef CebulskiCenter for Innovation and Transfer of Natural Sciences and Engineering Knowledge, University of Rzeszow, 35-310 Rzeszow, Poland.
Radosław ChaberDepartment of Pediatrics, Institute of Medical Sciences, University of Rzeszow, 35-310 Rzeszow, Poland.ORCID 0000-0002-6862-9142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMedulloblastoma (MB) is the most common malignant tumor of the central nervous system in childhood. FTIR spectroscopy provides a holistic view of the chemical composition of biological samples, including the detection of molecules such as nucleic acids, proteins, and lipids. This study evaluated the applicability of FTIR spectroscopy as a potential diagnostic tool for MB. MATERIALS AND

methodsFTIR spectra of MB samples from 40 children (boys/girls: 31/9; age: median 7.8 years, range 1.5-21.5 years) treated in the Oncology Department of the Children's Memorial Health Institute in Warsaw between 2010 and 2019 were analyzed. The control group consisted of normal brain tissue taken from four children diagnosed with causes other than cancer. Formalin-fixed and paraffin-embedded tissues were sectioned and used for FTIR spectroscopic analysis. The sections were examined in the mid-infrared range (800-3500 cm

resultsFTIR spectra in MB were significantly different from those of normal brain tissue. The most significant differences related to the range of nucleic acids and proteins in the region 800-1800 cm

conclusionsMB and normal brain tissue can be distinguished from one another to some extent using FTIR spectroscopy. As a result, it may be used as a further tool to hasten and enhance histological diagnosis.

Indexed as

Cerebellar NeoplasmsMedulloblastomaNucleic AcidsAdolescentAdultChildChild, PreschoolFemaleHumansInfantMaleProteinsSpectroscopy, Fourier Transform InfraredYoung AdultNucleic AcidsProteinsFourier transform infrared spectroscopyFTIR spectroscopyMBmedulloblastoma

Identifiers

PMID36903631
PMCPMC10005236

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.