Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System.

Khadijah M Al-Zaydi, Tamer S Saleh, Norah F Alqahtani, Meaad S Bagazi

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Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Khadijah M Al-ZaydiDepartment of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia.

Tamer S SalehDepartment of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia.ORCID 0000-0001-8367-4964

Norah F AlqahtaniDepartment of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia.

Meaad S BagaziDepartment of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia.

Funding

the Deputyship for Research & Innovation, Minis-try of Education in Saudi Arabia for funding this research work MoE-IF-G-20-04

6 · The paper itself

Abstract

We reported herein efficient economic high-pressure synthesis procedures for the synthesis of bis(azoles) and bis(azines) by utilizing the bis(enaminone) intermediate. Bis(enaminone) reacted with hydrazine hydrate, hydroxylamine hydrochloride, guanidine hydrochloride, urea, thiourea, and malononitrile to form the desired bis azines and bis azoles. A combination of elemental analyses and spectral data was used to confirm the structures of the products. Compared with conventional heating, the high-pressure Q-Tube method promotes reactions in a short period of time and provides high yields.

Indexed as

bis(azines)bis(azoles)bis(pyridine enaminone)green chemistryQ-Tube reactor

Identifiers

PMID36903598

DOI10.3390/molecules28052355

PMCPMC10005632

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