Evidence map›Paper›PMID 36903581›Full record

ReviewMolecules (Basel, Switzerland)2023

Cell Membrane Biomimetic Nanoparticles with Potential in Treatment of Alzheimer's Disease.

Xinyu Zhong, Yue Na, Shun Yin, Chang Yan, Jinlian Gu, Ning Zhang, Fang Geng

Full text readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
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  7. Nanoparticles as an Encouraging Therapeutic Approach to Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Review
  10. Nano-structured strategies in combatting neurodegeneration.Frontiers in bioengineering and biotechnology · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyu ZhongSchool of Chemistry & Chemical Engineering, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Yue NaSchool of Chemistry & Chemical Engineering, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Shun YinSchool of Chemistry & Chemical Engineering, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Chang YanSchool of Chemistry & Chemical Engineering, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Jinlian GuSchool of Chemistry & Chemical Engineering, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.
Ning ZhangCollege of Jiamusi, Heilongjiang University of Chinese Medicine, Harbin 150004, China.ORCID 0000-0003-0399-5085
Fang GengSchool of Chemistry & Chemical Engineering, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China.

Funding

This work was supported by the National Natural Science Foundation of China (82174007) This work was supported by the National Natural Science Foundation of China (82174007)
6 · The paper itself

Abstract

Alzheimer's disease (AD) is to blame for about 60% of dementia cases worldwide. The blood-brain barrier (BBB) prevents many medications for AD from having clinical therapeutic effects that can be used to treat the affected area. Many researchers have turned their attention to cell membrane biomimetic nanoparticles (NPs) to solve this situation. Among them, NPs can extend the half-life of drugs in the body as the "core" of the wrapped drug, and the cell membrane acts as the "shell" of the wrapped NPs to functionalize the NPs, which can further improve the delivery efficiency of nano-drug delivery systems. Researchers are learning that cell membrane biomimetic NPs can circumvent the BBB's restriction, prevent harm to the body's immune system, extend the period that NPs spend in circulation, and have good biocompatibility and cytotoxicity, which increases efficacy of drug release. This review summarized the detailed production process and features of core NPs and further introduced the extraction methods of cell membrane and fusion methods of cell membrane biomimetic NPs. In addition, the targeting peptides for modifying biomimetic NPs to target the BBB to demonstrate the broad prospects of cell membrane biomimetic NPs drug delivery systems were summarized.

Indexed as

Alzheimer DiseaseNanoparticlesBiomimeticsBlood-Brain BarrierCell MembraneHumansAlzheimer’s diseaseblood–brain barriercell membrane biomimetic nanoparticlestargeting peptides

Identifiers

PMID36903581
PMCPMC10005336

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.