Evidence map›Paper›PMID 36903567›Full record

ArticleMolecules (Basel, Switzerland)2023

Design and Synthesis of New Acyl Urea Analogs as Potential σ1R Ligands.

Rajesh Thapa, Rafael Flores, Kwan H Cheng, Bereket Mochona, Donald Sikazwe

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Rajesh ThapaPharmaceutical Sciences Department, Feik School of Pharmacy, University of the Incarnate Word, San Antonio, TX 78209, USA.
Rafael FloresPharmaceutical Sciences Department, Feik School of Pharmacy, University of the Incarnate Word, San Antonio, TX 78209, USA.ORCID 0009-0004-5329-0846
Kwan H ChengDepartment of Physics and Astronomy and Neuroscience Program, Trinity University, San Antonio, TX 78212, USA.
Bereket MochonaDepartment of Chemistry, Florida A&M University, Tallahassee, FL 32307, USA.
Donald SikazwePharmaceutical Sciences Department, Feik School of Pharmacy, University of the Incarnate Word, San Antonio, TX 78209, USA.ORCID 0000-0003-1109-6872
University of the Incarnate Word · USFlorida Agricultural and Mechanical University · USTrinity University · US

Funding

Single molecules with multi-mechanistic modes of action as probative anti-Alzheimer’s agentsSC3GM140980 · NIGMS · UNIVERSITY OF THE INCARNATE WORD · PI SIKAZWE, DONALD M · 2021 to 2024
$394k
NIGMS NIH HHS SC3 GM140980NIH HHS SC3GM140980
6 · The paper itself

Abstract

In search of synthetically accessible open-ring analogs of PD144418 or 5-(1-propyl-1,2,5,6-tetrahydropyridin-3-yl)-3-(p-tolyl)isoxazole, a highly potent sigma-1 receptor (σ1R) ligand, we herein report the design and synthesis of sixteen arylated acyl urea derivatives. Design aspects included modeling the target compounds for drug-likeness, docking at σ1R crystal structure 5HK1, and contrasting the lower energy molecular conformers with that of the receptor-embedded PD144418-a molecule we opined that our compounds could mimic pharmacologically. Synthesis of our acyl urea target compounds was achieved in two facile steps which involved first generating the

Indexed as

Receptors, sigmaAminesLigandsSigma-1 ReceptorAminesLigandsReceptors, sigmaSigma-1 Receptoracyl-ureaconformersdrug-likenessisoxazolemodelling

Identifiers

PMID36903567
PMCPMC10005056
OpenAlexW4323044721

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read96
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.