A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging.

Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua

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Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Chenglin LiKey Laboratory for Advanced Materials, Joint International Research Laboratory for Precision Chemistry and Molecular Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Sifan LiKey Laboratory for Advanced Materials, Joint International Research Laboratory for Precision Chemistry and Molecular Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Xinsheng LiKey Laboratory for Advanced Materials, Joint International Research Laboratory for Precision Chemistry and Molecular Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Tao YuanKey Laboratory for Advanced Materials, Joint International Research Laboratory for Precision Chemistry and Molecular Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Jialei XuKey Laboratory for Advanced Materials, Joint International Research Laboratory for Precision Chemistry and Molecular Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Xixin GuKey Laboratory for Advanced Materials, Joint International Research Laboratory for Precision Chemistry and Molecular Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Jianli HuaKey Laboratory for Advanced Materials, Joint International Research Laboratory for Precision Chemistry and Molecular Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Funding

National Natural Science Foundation of China 21788102, 22271093, 21772040 and 21971064the Fundamental Research Funds for the central universities 222201717003 and 50321101918001

6 · The paper itself

Abstract

Carboxylesterases (CEs) play important physiological roles in the human body and are involved in numerous cellular processes. Monitoring CEs activity has great potential for the rapid diagnosis of malignant tumors and multiple diseases. Herein, we developed a new phenazine-based "turn-on" fluorescent probe DBPpys by introducing 4-bromomethyl-phenyl acetate to DBPpy, which can selectively detect CEs with a low detection limit (9.38 × 10

Indexed as

Carboxylic Ester HydrolasesFluorescent DyesCell SurvivalHeLa CellsHumansHydrogen PeroxideLipid DropletsOptical ImagingCarboxylic Ester HydrolasesFluorescent DyesHydrogen Peroxidecarboxylesterases detectionfluorescent probelarge Stokes shiftlipid droplets targetingnear-infrared emission

Identifiers

PMID36903562

DOI10.3390/molecules28052317

PMCPMC10005208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.