Evidence map›Paper›PMID 36903494›Full record

ArticleMolecules (Basel, Switzerland)2023

Multiepitope Subunit Peptide-Based Nanovaccine against Porcine Circovirus Type 2 (PCV2) Elicited High Antibody Titers in Vaccinated Mice.

Viet Tram Duong, Prashamsa Koirala, Sung-Po R Chen, Michael J Monteiro, Mariusz Skwarczynski, Istvan Toth

Full text read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Automated Synthesis and Purification of Hydrophobic Peptides.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Viet Tram DuongSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.ORCID 0000-0002-1284-0838
Prashamsa KoiralaSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.ORCID 0000-0003-4436-364X
Sung-Po R ChenAustralian Institute of Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
Michael J MonteiroAustralian Institute of Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
Mariusz SkwarczynskiSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.ORCID 0000-0001-7257-807X
Istvan TothSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.

Funding

Australian Research Council DP210101280National Health and Medical Research Council APP1132975
6 · The paper itself

Abstract

Porcine circovirus 2 (PCV2) infection is one of the most serious threats to the swine industry. While the disease can be prevented, to some extent, by commercial PCV2a vaccines, the evolving nature of PCV2 necessitates the development of a novel vaccine that can compete with the mutations of the virus. Thus, we have developed novel multiepitope vaccines based on the PCV2b variant. Three PCV2b capsid protein epitopes, together with a universal T helper epitope, were synthesized and formulated with five delivery systems/adjuvants: complete Freund's adjuvant, poly(methyl acrylate) (PMA), poly(hydrophobic amino acid), liposomes and rod-shaped polymeric nanoparticles built from polystyrene-poly(

Indexed as

CircovirusSwine DiseasesViral VaccinesAdjuvants, ImmunologicAnimalsAntibodies, ViralEpitopesMicePeptidesSwineAdjuvants, ImmunologicAntibodies, ViralEpitopesPeptidesViral Vaccinesadjuvantblock copolymersliposomenanoparticlespeptide-based vaccinepolyleucinepoly(methyl acrylate)porcine circovirusrods

Identifiers

PMID36903494
PMCPMC10005372

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read135
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.