Evidence map›Paper›PMID 36903457›Full record

ArticleMolecules (Basel, Switzerland)2023

Comparison of the Determination of Some Antihypertensive Drugs in Clinical Human Plasma Samples by Solvent Front Position Extraction and Precipitation Modes.

Kamila Jaglińska, Beata Polak, Anna Klimek-Turek, Emilia Fornal, Anna Stachniuk, Alicja Trzpil, Robert Błaszczyk, Andrzej Wysokiński

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Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kamila JaglińskaDepartment of Physical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland.
Beata PolakDepartment of Physical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland.ORCID 0000-0003-4237-648X
Anna Klimek-TurekDepartment of Physical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland.
Emilia FornalDepartment of Bioanalytics, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.ORCID 0000-0002-0503-0706
Anna StachniukDepartment of Bioanalytics, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.ORCID 0000-0001-6384-1999
Alicja TrzpilDepartment of Bioanalytics, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.
Robert BłaszczykChair and Department of Cardiology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.ORCID 0000-0003-1853-5006
Andrzej WysokińskiChair and Department of Cardiology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The determination of the selected antihypertensive drugs in human plasma samples with the novel solvent front position extraction (SFPE) technique is presented. The SFPE procedure combined with LC-MS/MS analysis was used for the first time to prepare a clinical sample containing the drugs mentioned above from different therapeutic groups. The effectiveness of our approach was compared with the precipitation method. The latter technique is usually used to prepare biological samples in routine laboratories. During the experiments, the substances of interest and the internal standard were separated from other matrix components using a prototype horizontal chamber for thin-layer chromatography/high-performance thin-layer chromatography (TLC/HPTLC) with a moving pipette powered by a 3D mechanism, which distributed the solvent on the adsorbent layer. Detection of the six antihypertensive drugs was performed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in multiple reaction monitoring (MRM) mode. Results obtained by SFPE were very satisfactory (linearity R

Indexed as

Antihypertensive AgentsTandem Mass SpectrometryChromatography, High Pressure LiquidChromatography, LiquidHumansSolventsAntihypertensive AgentsSolventsantihypertensive drugsclinical sample preparationLC-MS/MS analysisprecipitationsolvent front position extraction

Identifiers

PMID36903457
PMCPMC10004659

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.