Evidence map›Paper›PMID 36903456›Full record

ArticleMolecules (Basel, Switzerland)2023

CSDR Coupling with Exo III for Ultrasensitive Electrochemistry Determination of miR-145.

Moli Zhang, Yang Yang, Lingyi Xin, Hua Zhang, Lun Wu, Jun Zhu, Jing Zhu, Shiyun Liu, Zhaohui Wang, Qinhua Chen and 1 more

Full text read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Moli ZhangShenzhen Bao'an Authentic TCM Therapy Hospital, Shenzhen 518102, China.
Yang YangShenzhen Bao'an Authentic TCM Therapy Hospital, Shenzhen 518102, China.
Lingyi XinShenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China.
Hua ZhangSinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan 430345, China.
Lun WuSinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan 430345, China.
Jun ZhuSinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan 430345, China.
Jing ZhuShenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China.
Shiyun LiuSinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan 430345, China.
Zhaohui WangShenzhen Bao'an Authentic TCM Therapy Hospital, Shenzhen 518102, China.
Qinhua ChenShenzhen Bao'an Authentic TCM Therapy Hospital, Shenzhen 518102, China.ORCID 0000-0002-9108-1314
Guangyi YangShenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China.

Funding

Foundation of Health Commission of Hubei Province WJ2021F052 and WJ2021M063Sanming Project of Medicine in Shenzhen SZZYSM202106004Scientific research project of Guangdong Provincial Bureau of traditional Chinese Medicine 20221336the National Natural Science Foundation of China 81872509
6 · The paper itself

Abstract

Recently, miRNAs have become a promising biomarker for disease diagnostics. miRNA-145 is closely related to strokes. The accuracy determination of miRNA-145 (miR-145) in stroke patients still remains challenging due to its heterogeneity and low abundance, as well as the complexity of the blood matrix. In this work, we developed a novel electrochemical miRNA-145 biosensor via subtly coupling the cascade strand displacement reaction (CSDR), exonuclease III (Exo III), and magnetic nanoparticles (MNPs). The developed electrochemical biosensor can quantitatively detect miRNA-145 ranging from 1 × 10

Indexed as

Biosensing TechniquesMicroRNAsElectrochemical TechniquesElectrochemistryExodeoxyribonucleasesHumansLimit of Detectionexodeoxyribonuclease IIIExodeoxyribonucleasesMicroRNAsMIRN145 microRNA, humanCSDRelectrochemistryExo IIImiRNA-145MNPsstroke

Identifiers

PMID36903456
PMCPMC10005534

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.