Evidence map›Paper›PMID 36903360›Full record

ArticleMolecules (Basel, Switzerland)2023

Sortase A Inhibitor Protein Nanoparticle Formulations Demonstrate Antibacterial Synergy When Combined with Antimicrobial Peptides.

Sitah Alharthi, Amirali Popat, Zyta Maria Ziora, Peter Michael Moyle

Full text read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sitah AlharthiSchool of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, QLD 4102, Australia.ORCID 0000-0003-0031-5654
Amirali PopatSchool of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, QLD 4102, Australia.
Zyta Maria ZioraInstitute for Molecular Bioscience (IMB), The University of Queensland, St Lucia, QLD 4072, Australia.
Peter Michael MoyleSchool of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, QLD 4102, Australia.ORCID 0000-0002-9247-681X

Funding

Metagenics N/AThe University of Queensland, Faculty of Health and Behavioural Sciences (HaBS) N/AThe University of Queensland, School of Pharmacy N/A
6 · The paper itself

Abstract

Sortase A (SrtA) is an enzyme which attaches proteins, including virulence factors, to bacterial cell walls. It is a potential target for developing anti-virulence agents against pathogenic and antimicrobial resistant bacteria. This study aimed to engineer 𝛽-lactoglobulin protein nanoparticles (PNPs) for encapsulating safe and inexpensive natural SrtA inhibitors (SrtAIs;

Indexed as

Methicillin-Resistant Staphylococcus aureusNanoparticlesAminoacyltransferasesAnti-Bacterial AgentsAntimicrobial PeptidesBacteriaBacterial ProteinsCysteine EndopeptidasesEscherichia coliHEK293 CellsHumansMicrobial Sensitivity TestsStaphylococcus aureusAminoacyltransferasesAnti-Bacterial AgentsAntimicrobial PeptidesBacterial ProteinsCysteine Endopeptidasessortase Aantimicrobial resistance?-lactoglobulinprotein nanoparticlessortase A inhibitorssynergy

Identifiers

PMID36903360
PMCPMC10004702

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read100
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.