Evidence map›Paper›PMID 36903345›Full record

ArticleMolecules (Basel, Switzerland)2023

Exploration of Pyrido[3,4-

Max Van Hoof, Sandra Claes, Katrijn Boon, Tom Van Loy, Dominique Schols, Wim Dehaen, Steven De Jonghe

Open access · goldFull text read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Max Van HoofMolecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.ORCID 0000-0001-5396-9892
Sandra ClaesDepartment of Microbiology, Immunology and Transplantation-Laboratory of Virology and Chemotherapy, KU Leuven-Rega Institute for Medical Research, Herestraat 49, B-3000 Leuven, Belgium.
Katrijn BoonDepartment of Microbiology, Immunology and Transplantation-Laboratory of Virology and Chemotherapy, KU Leuven-Rega Institute for Medical Research, Herestraat 49, B-3000 Leuven, Belgium.ORCID 0000-0002-8948-0287
Tom Van LoyDepartment of Microbiology, Immunology and Transplantation-Laboratory of Virology and Chemotherapy, KU Leuven-Rega Institute for Medical Research, Herestraat 49, B-3000 Leuven, Belgium.ORCID 0000-0003-2524-7264
Dominique ScholsDepartment of Microbiology, Immunology and Transplantation-Laboratory of Virology and Chemotherapy, KU Leuven-Rega Institute for Medical Research, Herestraat 49, B-3000 Leuven, Belgium.ORCID 0000-0003-3256-5850
Wim DehaenMolecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.ORCID 0000-0002-9597-0629
Steven De JongheDepartment of Microbiology, Immunology and Transplantation-Laboratory of Virology and Chemotherapy, KU Leuven-Rega Institute for Medical Research, Herestraat 49, B-3000 Leuven, Belgium.ORCID 0000-0002-3872-6558
Rega Institute for Medical Research · BEKU Leuven · BE

Funding

CELSA xxKU Leuven C14/19/078
6 · The paper itself

Abstract

Upregulated CXCR2 signalling is found in numerous inflammatory, autoimmune and neurodegenerative diseases, as well as in cancer. Consequently, CXCR2 antagonism is a promising therapeutic strategy for treatment of these disorders. We previously identified, via scaffold hopping, a pyrido[3,4-

Indexed as

NeoplasmsReceptors, ChemokineReceptors, Interleukin-8BHumansPyrimidinesStructure-Activity RelationshipCXCR2 protein, humanPyrimidinesReceptors, ChemokineReceptors, Interleukin-8BCXCR2 antagonistspyrido[3,4-d]pyrimidinesSAR study

Identifiers

PMID36903345
PMCPMC10004157
OpenAlexW4321789474

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read395
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.