Evidence map›Paper›PMID 36903325›Full record

ArticleMolecules (Basel, Switzerland)2023

Two Ferulic Acid Derivatives Inhibit Neuroinflammatory Response in Human HMC3 Microglial Cells via NF-

Pei-Lin Li, Xiao-Xue Zhai, Jun Wang, Xiang Zhu, Lin Zhao, Shuang You, Chun-Yan Sang, Jun-Li Yang

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In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Identification of Hypolipidemic Constituents fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. p65 enhanced METTL3-mediated mCentral-European journal of immunology · 2025
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pei-Lin LiCAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China.
Xiao-Xue ZhaiCollege of Chemical Engineering, Northwest Minzu University, Lanzhou 730030, China.
Jun WangShandong Laboratory of Yantai Advanced Materials and Green Manufacturing, Yantai 264000, China.
Xiang ZhuYaomazi Food Co., Ltd., Hongya 620360, China.
Lin ZhaoYaomazi Food Co., Ltd., Hongya 620360, China.
Shuang YouYaomazi Food Co., Ltd., Hongya 620360, China.
Chun-Yan SangCAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China.
Jun-Li YangCAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China.

Funding

CAS "Light of West China" Program, LICP Cooperation Foundation for Young Scholars, Key Research and Development Project of Sichuan Province 2022YFN0019National Key Research and Development Project 2018YFE0182500the foundation of Chinese Academy of Sciences via Special Research Assistant Program No. E20458YZthe scientific research programs of Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing E1R03SXM04 and AMGM2021A10
6 · The paper itself

Abstract

Various physiological and pathological changes are related to the occurrence and development of neurodegenerative diseases. Neuroinflammation is a major trigger and exacerbation of neurodegenerative diseases. One of the main symptoms of neuritis is the activation of microglia. Thus, to alleviate the occurrence of neuroinflammatory diseases, an important method is to inhibit the abnormal activation of microglia. This research evaluated the inhibitory effect of trans-ferulic acid (TJZ-1) and methyl ferulate (TJZ-2), isolated from

Indexed as

MicrogliaNF-kappa BCoumaric AcidsHumansInflammationLipopolysaccharidesNeuroinflammatory DiseasesNitric OxideSignal TransductionTumor Necrosis Factor-alphaCoumaric Acidsferulic acidLipopolysaccharidesNF-kappa BNitric OxideTumor Necrosis Factor-alphaferulic acidHMC3neuroinflammationNF-κB signaling pathwayZanthoxylum armatum

Identifiers

PMID36903325
PMCPMC10004133

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.