Evidence map›Paper›PMID 36903298›Full record

ArticleMolecules (Basel, Switzerland)2023

Molecularly Imprinted Polymer Nanospheres with Hydrophilic Shells for Efficient Molecular Recognition of Heterocyclic Aromatic Amines in Aqueous Solution.

Peijian Sun, Yipeng Wang, Song Yang, Xuehui Sun, Bin Peng, Lining Pan, Yunzhen Jia, Xiaobing Zhang, Cong Nie

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In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peijian SunKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC (China National Tobacco Corporation), No. 2 Fengyang Street, Zhengzhou 450001, China.
Yipeng WangKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC (China National Tobacco Corporation), No. 2 Fengyang Street, Zhengzhou 450001, China.
Song YangKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC (China National Tobacco Corporation), No. 2 Fengyang Street, Zhengzhou 450001, China.
Xuehui SunKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC (China National Tobacco Corporation), No. 2 Fengyang Street, Zhengzhou 450001, China.
Bin PengKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC (China National Tobacco Corporation), No. 2 Fengyang Street, Zhengzhou 450001, China.
Lining PanKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC (China National Tobacco Corporation), No. 2 Fengyang Street, Zhengzhou 450001, China.
Yunzhen JiaKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC (China National Tobacco Corporation), No. 2 Fengyang Street, Zhengzhou 450001, China.
Xiaobing ZhangKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC (China National Tobacco Corporation), No. 2 Fengyang Street, Zhengzhou 450001, China.
Cong NieKey Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC (China National Tobacco Corporation), No. 2 Fengyang Street, Zhengzhou 450001, China.

Funding

Natural Science Foundation of Henan 212300410314
6 · The paper itself

Abstract

Heterocyclic aromatic amine molecularly imprinted polymer nanospheres with surface-bound dithioester groups (haa-MIP) were firstly synthesized via reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization. Then, a series of core-shell structural heterocyclic aromatic amine molecularly imprinted polymer nanospheres with hydrophilic shells (MIP-HSs) were subsequently prepared by grafting the hydrophilic shells on the surface of haa-MIP via on-particle RAFT polymerization of 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA), and diethylaminoethyl methacrylate (DEAEMA). The haa-MIP nanospheres showed high affinity and specific recognition toward harmine and its structural analogs in organic solution of acetonitrile, but lost the specific binding ability in aqueous solution. However, after the grafting of the hydrophilic shells on the haa-MIP particles, the surface hydrophilicity and water dispersion stability of the polymer particles of MIP-HSs greatly improved. The binding of harmine by MIP-HSs with hydrophilic shells in aqueous solutions is about two times higher than that of NIP-HSs, showing an efficient molecular recognition of heterocyclic aromatic amines in aqueous solution. The effect of hydrophilic shell structure on the molecular recognition property of MIP-HSs was further compared. MIP-PIA with carboxyl groups containing hydrophilic shells showed the highest selective molecular recognition ability to heterocyclic aromatic amines in aqueous solution.

Indexed as

core-shellheterocyclic aromatic amineshydrophilic shellsmolecularly imprinted polymers

Identifiers

PMID36903298
PMCPMC10004106

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