Evidence map›Paper›PMID 36903295›Full record

ReviewMolecules (Basel, Switzerland)2023

Emerging Immunotherapeutic and Diagnostic Modalities in Carcinoid Tumors.

Shahnaz D Vellani, Anthony Nigro, Shangari Varatharajan, Lance D Dworkin, Justin Fortune Creeden

Full text readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shahnaz D VellaniDepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0000-0001-5750-9084
Anthony NigroDepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0000-0002-1369-0309
Shangari VaratharajanDepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Lance D DworkinDepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Justin Fortune CreedenDepartment of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0000-0003-3123-8401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evasion of innate immunity represents a frequently employed method by which tumor cells survive and thrive. Previously, the development of immunotherapeutic agents capable of overcoming this evasion has realized pronounced clinical utility across a variety of cancer types. More recently, immunological strategies have been investigated as potentially viable therapeutic and diagnostic modalities in the management of carcinoid tumors. Classic treatment options for carcinoid tumors rely upon surgical resection or non-immune pharmacology. Though surgical intervention can be curative, tumor characteristics, such as size, location, and spread, heavily limit success. Non-immune pharmacologic treatments can be similarly limited, and many demonstrate problematic side effects. Immunotherapy may be able to overcome these limitations and further improve clinical outcomes. Similarly, emerging immunologic carcinoid biomarkers may improve diagnostic capabilities. Recent developments in immunotherapeutic and diagnostic modalities of carcinoid management are summarized here.

Indexed as

Carcinoid TumorBiomarkersHumansImmunologic FactorsBiomarkersImmunologic Factorsbiomarkerscarcinoidimmunotherapyneuroendocrinetumors

Identifiers

PMID36903295
PMCPMC10004351

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read64
identifiers read15
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.