Evidence map›Paper›PMID 36903279›Full record

ArticleMolecules (Basel, Switzerland)2023

Ultrasound-Assisted Extraction of Total Phenolic Compounds and Antioxidant Activity Evaluation from Oregano (

Afroditi Michalaki, Haralabos C Karantonis, Anastasia S Kritikou, Nikolaos S Thomaidis, Marilena E Dasenaki

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In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Bioactive Flavonoids and Phenolic Acids ofCurrent drug discovery technologies · 2026
    Article
  5. Green, Ultrasound-Assisted Extraction for Carvacrol-RichMolecules (Basel, Switzerland) · 2025
    Article
  6. Gels (Basel, Switzerland) · 2025
    Article
  7. Extraction, purification and antioxidant activity of flavonoids fromFrontiers in bioengineering and biotechnology · 2025
    Article
  8. Review
  9. Antimicrobial and Antibiofilm Activity ofMolecules (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Afroditi MichalakiLaboratory of Food Chemistry, Biochemistry and Technology, Department of Food Science and Nutrition, School of the Environment, University of The Aegean, 81400 Lemnos, Greece.
Haralabos C KarantonisLaboratory of Food Chemistry, Biochemistry and Technology, Department of Food Science and Nutrition, School of the Environment, University of The Aegean, 81400 Lemnos, Greece.ORCID 0000-0003-1134-7811
Anastasia S KritikouLaboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0002-4673-2982
Nikolaos S ThomaidisLaboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0002-4624-4735
Marilena E DasenakiLaboratory of Food Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0002-0853-4547

Funding

EPAnEk -NRSF 2014-2020 5046750
6 · The paper itself

Abstract

Oregano is native to the Mediterranean region and it has been reported to contain several phenolic compounds particularly flavonoids that have been related with multiple bioactivities towards certain diseases. Oregano is cultivated in the island of Lemnos where the climate promotes its growth and thus it could be further used in promoting local economy. The aim of the present study was to establish a methodology for the extraction of total phenolic content along with the antioxidant capacity of oregano by using response surface methodology. A Box-Behnken design was applied to optimize the extraction conditions with regard to the extraction time, temperature, and solvent mixture with the use of ultrasound-assisted extraction. For the optimized extracts, identification of the most abundant flavonoids (luteolin, kaempferol, and apigenin) was performed with an analytical HPLC-PDA and UPLC-Q-TOF MS methodology. The predicted optimal conditions of the statistical model were identified, and the predicted values confirmed. The linear factors evaluated, temperature, time, and ethanol concentration, all showed significant effect (

Indexed as

AntioxidantsOriganumChromatography, High Pressure LiquidFlavonoidsPhenolsPlant ExtractsTandem Mass SpectrometryAntioxidantsFlavonoidsPhenolsPlant Extractsantioxidantsbox–behnkenHPLC-PDA analysisoreganophenolicsUPLC-Q-TOF MS

Identifiers

PMID36903279
PMCPMC10004109

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.