Associations of Tinnitus Incidence with Use of Tumor Necrosis Factor-Alpha Inhibitors among Patients with Autoimmune Conditions.

Nirvikalpa Natarajan, Shelley Batts, Saurabh Gombar, Raj Manickam, Varun Sagi, Sharon G Curhan, Konstantina M Stankovic

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Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling.Cell · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nirvikalpa NatarajanDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd, Palo Alto, CA 94304, USA.

Shelley BattsDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd, Palo Alto, CA 94304, USA.

Saurabh GombarAtropos Health, 71 W 83rd St #3R., New York, NY 10024, USA.

Raj ManickamAtropos Health, 71 W 83rd St #3R., New York, NY 10024, USA.

Varun SagiDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd, Palo Alto, CA 94304, USA.

Sharon G CurhanChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.ORCID 0000-0003-0282-0822

Konstantina M StankovicDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd, Palo Alto, CA 94304, USA.

Funding

Bertarelli Foundation Endowed Professorship N/ALarry Bowman N/ARemondi Foundation N/ARich Robbins N/A

6 · The paper itself

Abstract

Tumor necrosis factor-alpha (TNFα) may promote neuroinflammation prompting tinnitus. This retrospective cohort study evaluated whether anti-TNFα therapy influences incident tinnitus risk among adults with autoimmune disorders and no baseline tinnitus selected from a US electronic health records database (Eversana; 1 January 2010-27 January 2022). Patients with anti-TNFα had ≥90-day history pre-index (first autoimmune disorder diagnosis) and ≥180-day follow-up post-index. Random samples (

Indexed as

autoimmune disorderscohort studyelectronic health recordsincidencepropensity score matchingtinnitustumor necrosis factor-alphatumor necrosis factor-alpha inhibitor

Identifiers

PMID36902722

DOI10.3390/jcm12051935

PMCPMC10004033

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.