ReviewJournal of clinical medicine2023
White Spot Lesions (WSLs)-Post-Orthodontic Occurrence, Management and Treatment Alternatives: A Narrative Review.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06797882 (The Effectiveness of Silver Diamine Fluoride), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effectiveness of Silver Diamine Fluoride (SDF) in the Prevention of Early Enamel Caries Among Patients With Fixed Orthodontic Appliances: A Randomised Controlled Trial
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of Self-Assembling Peptide on White Spot Lesions in Orthodontic Patients: A Systematic Review and Meta-Analysis.Clinical and experimental dental research · 2026Pooled it
- Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic brackets: a systematic review of in vitro studies.BMC oral health · 2024Pooled it
- Distribution of initial caries lesions in relation to fixed orthodontic therapy. A systematic review and meta-analysis.European journal of orthodontics · 2024Pooled it
- Antibacterial effects of silver and titanium dioxide nanoparticles-coated orthodontic arch wires: in vitro study.BMC oral health · 2026Article
- Optimization of In Vitro White Spot Lesion Protocol: Comparative Diagnostics via Visual Inspection, Scanning Electron Microscopy, and Fluorescence Methods.Diagnostics (Basel, Switzerland) · 2026Article
- Enhanced remineralization and acid resistance of white spot lesions by combined bioactive glass and resin infiltration: an in vitro study.BMC oral health · 2026Article
- Development and application of a multidimensional instrument to evaluate competency discrepancies in orthodontic practice.BMC oral health · 2026Article
- Influence of White Spot Lesion Severity on the Structural, Optical, and Mechanical Outcomes of Resin Infiltration: An In Vitro Study.Diagnostics (Basel, Switzerland) · 2026Article
- Evaluation of Microleakage Beneath Orthodontic Molar Bands Cemented With Resin-Modified Glass Ionomer Using Two Enamel Deproteinization Agents.International journal of dentistry · 2026Article
- Prevalence of white spot lesions in children and adolescents across Northern, Central and Southern Italy: a multicenter cross-sectional study.Frontiers in oral health · 2026Article
- Antimicrobial Resistance in Oral Healthcare: A Growing Concern in Dentistry.Dentistry journal · 2025Review
- Influence of Bioactive Glass Incorporation in Resin Adhesives of Orthodontic Brackets on Adhesion Properties and Calcium Release.Polymers · 2025Article
- Laser-assisted Icon and clinpro for restoring white spot lesions: an in vitro comparative study.Odontology · 2025Article
- Article
- A Novel Graphite Fluoride/Bioactive Glass-containing Orthodontic Primer with Antibacterial and Remineralization Properties: An In-vitro Study.The journal of adhesive dentistry · 2024Article
- Quality of occlusal outcome in adult Class II patients treated with completely customized lingual appliances and Class II elastics compared to adult Class I patients.European journal of orthodontics · 2024Article
- Impact of Calcium Lactate Pretreatment on Enamel Fluoride Uptake: A Comparative In Vitro Study of Different Fluoride Types and Concentrations.Journal of functional biomaterials · 2024Article
- Does orthodontic treatment using fixed appliances cause initial caries lesions?Evidence-based dentistry · 2024Article
- Article
- White Spot Lesions in Fixed Orthodontics: A Literature Review on Etiology, Prevention, and Treatment.Cureus · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although treatment with fixed or mobile appliances has become an important part of modern orthodontics, side effects such as white spot lesions (WSLs) have a negative impact on the aesthetic outcome of orthodontic treatment. The purpose of this article was to review current evidence on the diagnosis, risk assessment, prevention, management and post-orthodontic treatment of these lesions. Data collection was performed electronically, and the initial search using the keywords "white spot lesions", "orthodontics", "WSL", "enamel" and "demineralization" in different combinations resulted in 1032 articles for the two electronic databases used. Ultimately, a total of 47 manuscripts were considered relevant to the aim of this research and included in this review. The results of the review indicate that WSLs remain a significant problem during orthodontic treatment. According to studies in the literature, the severity of WSLs correlates to the duration of treatment. Using toothpaste with more than 1000 ppm fluoride at home reduces the frequency of WSL separation and regular application of varnishes in the office reduces the frequency of the occurrence of WSLs only in the context of maintaining a strict hygiene regime. The old hypothesis that elastomeric ligatures retain more dental plaque than metal ones has been refuted. There are no differences in the appearance of WSLs between conventional brackets and self-ligating brackets. Clear aligner mobile devices develop fewer WSLs but are more extensive as opposed to conventional fixed devices, while lingual orthodontic appliances have a lower incidence of WSLs, and the most effective device for preventing these lesions is WIN, followed by Incognito.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.