Evidence map›Paper›PMID 36902696›Full record

ReviewJournal of clinical medicine2023

White Spot Lesions (WSLs)-Post-Orthodontic Occurrence, Management and Treatment Alternatives: A Narrative Review.

Luminita Lazar, Alexandru Vlasa, Liana Beresescu, Anamaria Bud, Ana Petra Lazar, Larisa Matei, Eugen Bud

Registry-linked trialFull text readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06797882 (The Effectiveness of Silver Diamine Fluoride), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06797882 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Effectiveness of Silver Diamine Fluoride (SDF) in the Prevention of Early Enamel Caries Among Patients With Fixed Orthodontic Appliances: A Randomised Controlled Trial

TypeinterventionalSponsorNational University of MalaysiaRan2025 to 2026Enrolled99ConditionsDemineralization, Tooth, White Spot Lesion of Tooth, Fixed Appliances, Early Caries LesionsArmsSilver diamine fluoride- potassium iodide, Fluoride varnish, 0.9 % saline
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luminita LazarFaculty of Dental Medicine, University of Medicine and Pharmacy, Science and Technology George Emil Palade, 540139 Târgu-Mureș, Romania.ORCID 0000-0001-5499-4299
Alexandru VlasaFaculty of Dental Medicine, University of Medicine and Pharmacy, Science and Technology George Emil Palade, 540139 Târgu-Mureș, Romania.ORCID 0000-0003-3883-0547
Liana BeresescuFaculty of Dental Medicine, University of Medicine and Pharmacy, Science and Technology George Emil Palade, 540139 Târgu-Mureș, Romania.ORCID 0000-0002-0176-1894
Anamaria BudFaculty of Dental Medicine, University of Medicine and Pharmacy, Science and Technology George Emil Palade, 540139 Târgu-Mureș, Romania.
Ana Petra LazarFaculty of Dental Medicine, University of Medicine and Pharmacy, Science and Technology George Emil Palade, 540139 Târgu-Mureș, Romania.
Larisa MateiDepartment of Oral and Maxillo-Facial Surgery, Clinical Hospital of Târgu-Mureș, 540139 Târgu-Mureș, Romania.
Eugen BudFaculty of Dental Medicine, University of Medicine and Pharmacy, Science and Technology George Emil Palade, 540139 Târgu-Mureș, Romania.ORCID 0000-0001-5193-4944

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although treatment with fixed or mobile appliances has become an important part of modern orthodontics, side effects such as white spot lesions (WSLs) have a negative impact on the aesthetic outcome of orthodontic treatment. The purpose of this article was to review current evidence on the diagnosis, risk assessment, prevention, management and post-orthodontic treatment of these lesions. Data collection was performed electronically, and the initial search using the keywords "white spot lesions", "orthodontics", "WSL", "enamel" and "demineralization" in different combinations resulted in 1032 articles for the two electronic databases used. Ultimately, a total of 47 manuscripts were considered relevant to the aim of this research and included in this review. The results of the review indicate that WSLs remain a significant problem during orthodontic treatment. According to studies in the literature, the severity of WSLs correlates to the duration of treatment. Using toothpaste with more than 1000 ppm fluoride at home reduces the frequency of WSL separation and regular application of varnishes in the office reduces the frequency of the occurrence of WSLs only in the context of maintaining a strict hygiene regime. The old hypothesis that elastomeric ligatures retain more dental plaque than metal ones has been refuted. There are no differences in the appearance of WSLs between conventional brackets and self-ligating brackets. Clear aligner mobile devices develop fewer WSLs but are more extensive as opposed to conventional fixed devices, while lingual orthodontic appliances have a lower incidence of WSLs, and the most effective device for preventing these lesions is WIN, followed by Incognito.

Indexed as

cariesdental cavitiesdental decayenamel demineralizationorthodontic treatmentwhite spot lesion

Identifiers

PMID36902696
PMCPMC10003622

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read30
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.