ReviewJournal of clinical medicine2023
The Symptomatic Outcomes of Cholecystectomy for Gallstones.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Incidence risk and risk factors for postcholecystectomy syndrome: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Pooled it
- Differentiation of Gallbladder Adenomyomatosis and Polyps in a Western Cohort: Prevalence, Ultrasound Characteristics, and Diagnostic Challenges.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Unusual ivory-white gallstones identified during indocyanine green fluorescence-guided laparoscopic cholecystectomy: a rare case report.Frontiers in medicine · 2026Article
- Hepatic protein kinase Cβ antagonizing p38American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Pediatric gallbladder dyskinesia managed with laparoscopic cholecystectomy: A case report and literature review.International journal of surgery case reports · 2025Article
- Analysis of the incidence of post-cholecystectomy diarrhea and its influencing factors in Hainan Province.BMC gastroenterology · 2025Article
- Association of cholecystectomy with short-term and long-term risks of depression and suicide.Scientific reports · 2025Article
- Implementation of Pathway-Based Care for Patients Undergoing Daytime Cholecystectomy.Patient preference and adherence · 2025Article
- Severe gastrointestinal symptoms during first year after laparoscopic cholecystectomy.Pakistan journal of medical sciences · 2025Article
- High visceral adiposity and low skeletal muscle mass independently predict the development of acute cholecystitis in patients with gallstones: a retrospective cohort study.Frontiers in medicine · 2025Article
- Open versus laparoscopic completion cholecystectomy in patients with previous open partial cholecystectomy: a retrospective comparative study.Annals of medicine and surgery (2012) · 2024Article
- Article
- Evaluating the efficacy and safety of 2-methoxy-6-methylpyridine: a promising topical agent for gallstone dissolution in a porcine model.American journal of translational research · 2024Article
- A Machine Learning-Based Method for Detecting Liver Fibrosis.Diagnostics (Basel, Switzerland) · 2023Article
- Dysfunction of Biliary Sphincter of Oddi-Clinical, Diagnostic and Treatment Challenges.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholecystectomy is the definite treatment for symptomatic gallstones, and rates are rapidly rising. Symptomatic complicated gallstones are generally treated with cholecystectomy, but there is no consensus on the clinical selection of patients with symptomatic uncomplicated gallstones for cholecystectomy. The aim of this review is to describe symptomatic outcomes before versus after cholecystectomy in patients with symptomatic gallstones as reported in prospective clinical studies and to discuss patient selection for cholecystectomy. Following cholecystectomy, resolution of biliary pain is high and reported for 66-100%. Dyspepsia has an intermediate resolution of 41-91% and may co-exist with biliary pain but may also develop following cholecystectomy with an increase of 150%. Diarrhea has a high increase and debuts in 14-17%. Persisting symptoms are mainly determined by preoperative dyspepsia, functional disorders, atypical pain locations, longer duration of symptoms, and poor psychological or physical health. Patient satisfaction following cholecystectomy is high and may reflect symptom alleviation or a change in symptoms. Comparison of symptomatic outcomes in available prospective clinical studies is limited by variations in preoperative symptoms, clinical presentations, and clinical management of post-cholecystectomy symptoms. When selecting patients with biliary pain only in a randomized controlled trial, 30-40% still have persisting pain. Strategies for the selection of patients with symptomatic uncomplicated gallstones based on symptoms alone are exhausted. For the development of a selection strategy, future studies should explore the impact of objective determinants for symptomatic gallstones on pain relief following cholecystectomy.
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