Evidence map›Paper›PMID 36902616›Full record

ArticleJournal of clinical medicine2023

Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study.

Khadija Kacem-Berjeb, Marouen Braham, Cyrine Ben Massoud, Hela Hannachi, Manel Hamdoun, Sana Chtourou, Linda Debbabi, Maha Bouyahia, Anis Fadhlaoui, Fethi Zhioua and 3 more

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Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Open veterinary journal · 2025
    Article
  4. Review
  5. Effects of Endometriosis on Anti-Müllerian Hormone.Journal of clinical medicine · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Khadija Kacem-BerjebDepartment of Reproductive Biology and Cytogenetics, Aziza Othmana Hospital, University of Tunis, Tunis 1008, Tunisia.
Marouen BrahamResearch Laboratory LR16SP01 "Infertility and Oncofertility", Tunis 1008, Tunisia.ORCID 0000-0002-8861-3471
Cyrine Ben MassoudDepartment of Reproductive Biology and Cytogenetics, Aziza Othmana Hospital, University of Tunis, Tunis 1008, Tunisia.ORCID 0000-0002-3324-9529
Hela HannachiResearch Laboratory LR16SP01 "Infertility and Oncofertility", Tunis 1008, Tunisia.
Manel HamdounResearch Laboratory LR16SP01 "Infertility and Oncofertility", Tunis 1008, Tunisia.
Sana ChtourouDepartment of Reproductive Biology and Cytogenetics, Aziza Othmana Hospital, University of Tunis, Tunis 1008, Tunisia.ORCID 0000-0001-7572-2495
Linda DebbabiDepartment of Reproductive Biology and Cytogenetics, Aziza Othmana Hospital, University of Tunis, Tunis 1008, Tunisia.
Maha BouyahiaResearch Laboratory LR16SP01 "Infertility and Oncofertility", Tunis 1008, Tunisia.
Anis FadhlaouiDepartment of Gynecology and Obstetrics, Aziza Othmana Hospital, University of Tunis, Tunis 1008, Tunisia.
Fethi ZhiouaResearch Laboratory LR16SP01 "Infertility and Oncofertility", Tunis 1008, Tunisia.
Anis FekiDepartment of Obstetrics and Gynecology, Cantonal Hospital Fribourg, 1708 Fribourg, Switzerland.ORCID 0000-0002-9817-9445
Nozha ChakrounDepartment of Reproductive Biology and Cytogenetics, Aziza Othmana Hospital, University of Tunis, Tunis 1008, Tunisia.
Olfa BahriResearch Laboratory LR16SP01 "Infertility and Oncofertility", Tunis 1008, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes. MATERIALS AND

methodsIt is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other causes of infertility. All these patients were candidates for ICSI cycles. Their follicular fluid was collected at the time of oocyte retrieval and used to evaluate IL-6 and AMH titers by electro-chemiluminescent immunoassay (Cobas e411-Roche).

resultsThe IL-6 levels in follicular fluid were higher in the endometriosis group than in the control group (152.3 vs. 19.9 pg/mL;

conclusionsThe oocyte quality seems to be preserved in patients with endometriosis with the adequate response to ovarian stimulation. High levels of follicular IL6 are in accordance with the inflammatory phenomenon of the disease; however, this increase has no impact on ICSI outcomes.

Indexed as

AMHendometriosisIL6IVF

Identifiers

PMID36902616
PMCPMC10002901

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.