ArticleJournal of clinical medicine2023
Infiltration of Conduction Tissue Is a Major Cause of Electrical Instability in Cardiac Amyloidosis.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Incidental Diagnosis of TTR Amyloidosis During Left Bundle Branch Pacing Implantation: When Electrophysiology Meets Cardiomyopathy.JACC. Case reports · 2026Article
- Biomolecular mechanisms of cardiac amyloidosis and its cardiovascular pathological basis.Frontiers in immunology · 2026Review
- A role for defibrillation threshold testing? A case of ventricular fibrillation refractory to implantable cardioverter-defibrillator shocks in setting of cardiac amyloidosis.HeartRhythm case reports · 2025Article
- Electrocardiographic Patterns and Arrhythmias in Cardiac Amyloidosis: From Diagnosis to Therapeutic Management-A Narrative Review.Journal of clinical medicine · 2024Review
- Arrhythmic Risk Stratification in Cardiac Amyloidosis: A Review of the Current Literature.Journal of cardiovascular development and disease · 2024Review
- Thromboembolic and Bleeding Events in Transthyretin Amyloidosis and Coagulation System Abnormalities: A Review.Journal of clinical medicine · 2023Review
- Arrhythmic Manifestations of Cardiac Amyloidosis: Challenges in Risk Stratification and Clinical Management.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe pathology of conduction tissue (CT) and relative arrhythmias in living subjects with cardiac amyloid have never been reported.
aimsTo report CT pathology and its arrhythmic correlations in human cardiac amyloidosis. METHODS AND
resultsIn 17 out of 45 cardiac amyloid patients, a left ventricular endomyocardial biopsy included conduction tissue sections. It was identified by Aschoff-Monckeberg histologic criteria and positive immunostaining for HCN4. The degree of conduction tissue infiltration was defined as mild when ≤30%, moderate when 30-70% and severe when >70% cell area was replaced. Conduction tissue infiltration was correlated with ventricular arrhythmias, maximal wall thickness and type of amyloid protein. Mild involvement was observed in five cases, moderate in three and severe in nine. Involvement was associated with a parallel infiltration of conduction tissue artery. Conduction infiltration correlated with the severity of arrhythmias (Spearman rho = 0.8,
conclusionsAmyloid-associated cardiac arrhythmias correlate with the extent of conduction tissue infiltration. Its involvement is independent from type and severity of amyloidosis, suggesting a variable affinity of amyloid protein to conduction tissue.
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