Evidence map›Paper›PMID 36902485›Full record

ReviewInternational journal of molecular sciences2023

Impacts of Environmental Pollution on Brain Tumorigenesis.

Cristina Pagano, Giovanna Navarra, Laura Coppola, Beatrice Savarese, Giorgio Avilia, Antonella Giarra, Giovanni Pagano, Alessandra Marano, Marco Trifuoggi, Maurizio Bifulco and 1 more

Full text readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Ambient Air Pollution and Risk of Brain Tumors: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2026
    Pooled it
  2. FOLR1 Regulates the Malignant Progression of Glioblastoma through the SRC/ERK1/2 Axis.Combinatorial chemistry & high throughput screening · 2026
    Article
  3. Environmental Hazards and Glial Brain Tumors: Association or Causation?International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cristina PaganoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-9181-6595
Giovanna NavarraDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.
Laura CoppolaDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.
Beatrice SavareseDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.
Giorgio AviliaDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-5191-9506
Antonella GiarraDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.ORCID 0000-0003-1623-164X
Giovanni PaganoDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.
Alessandra MaranoDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.
Marco TrifuoggiDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.ORCID 0000-0002-6424-8676
Maurizio BifulcoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.
Chiara LaezzaInstitute of Endocrinology and Experimental Oncology (IEOS), National Research Council (CNR), 80131 Naples, Italy.

Funding

CALCITONIN GENE RELATED PEPTIDE AND AGINGR03AG018999 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI GANGULA, PANDU R · 2000 to 2000
$75k
POR FESR Regione Campania "Lotta al Covid" 2014-2020, FISR2020IP_01866 and AIRC18999, and Regione Campania (BURC: Legge 38/2020 art.16), Project:" Studi sulla lotta alle malattie ne-oplastiche FISR2020IP_01866, AIRC18999, Regione Campania (BURC: Legge 38/2020 art.16)
6 · The paper itself

Abstract

Pollutants consist of several components, known as direct or indirect mutagens, that can be associated with the risk of tumorigenesis. The increased incidence of brain tumors, observed more frequently in industrialized countries, has generated a deeper interest in examining different pollutants that could be found in food, air, or water supply. These compounds, due to their chemical nature, alter the activity of biological molecules naturally found in the body. The bioaccumulation leads to harmful effects for humans, increasing the risk of the onset of several pathologies, including cancer. Environmental components often combine with other risk factors, such as the individual genetic component, which increases the chance of developing cancer. The objective of this review is to discuss the impact of environmental carcinogens on modulating the risk of brain tumorigenesis, focusing our attention on certain categories of pollutants and their sources.

Indexed as

Air PollutantsAir PollutionBrain NeoplasmsBrainCarcinogenesisCell Transformation, NeoplasticEnvironmental ExposureEnvironmental MonitoringEnvironmental PollutionHumansAir Pollutantsbrain tumorenvironmental pollutantsenvironmental risk factorheavy metalstoxics

Identifiers

PMID36902485
PMCPMC10002587

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measurements read26
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.