Evidence map›Paper›PMID 36902462›Full record

ArticleInternational journal of molecular sciences2023

A Non-Invasive Method for Monitoring Osteogenesis and Osseointegration Using Near-Infrared Fluorescent Imaging: A Model of Maxilla Implantation in Rats.

Chien-Chou Lin, Li-Hsuan Chiu, Walter H Chang, Cheng-An J Lin, Ruei-Ming Chen, Yuan-Soon Ho, Chun S Zuo, Austin Changou, Yue-Fa Cheng, Wen-Fu T Lai

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Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chien-Chou LinGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Li-Hsuan ChiuMcLean Imaging Center, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA.
Walter H ChangDepartment of Biomedical Engineering, Chung Yuan Christian University, Taoyuan 320, Taiwan.
Cheng-An J LinDepartment of Biomedical Engineering, Chung Yuan Christian University, Taoyuan 320, Taiwan.
Ruei-Ming ChenGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0002-5728-0571
Yuan-Soon HoGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0002-3649-6680
Chun S ZuoMcLean Imaging Center, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA.
Austin ChangouPh.D. Program for Translational Medicine, College of Medicine and Technology, Taipei Medical University, Taipei 110, Taiwan.
Yue-Fa ChengCollege of Basic Medicine, North China University of Science and Technology, Tangshan 066008, China.
Wen-Fu T LaiMcLean Imaging Center, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, computed tomography and conventional X-ray radiography usually generate a micro-artifact around metal implants. This metal artifact frequently causes false positive or negative diagnoses of bone maturation or pathological peri-implantitis around implants. In an attempt to repair the artifacts, a highly specific nanoprobe, an osteogenic biomarker, and nano-Au-Pamidronate were designed to monitor the osteogenesis. In total, 12 Sprague Dawley rats were included in the study and could be chategorized in 3 groups: 4 rats in the X-ray and CT group, 4 rats in the NIRF group, and 4 rats in the sham group. A titanium alloy screw was implanted in the anterior hard palate. The X-ray, CT, and NIRF images were taken 28 days after implantation. The X-ray showed that the tissue surrounded the implant tightly; however, a gap of metal artifacts was noted around the interface between dental implants and palatal bone. Compared to the CT image, a fluorescence image was noted around the implant site in the NIRF group. Furthermore, the histological implant-bone tissue also exhibited a significant NIRF signal. In conclusion, this novel NIRF molecular imaging system precisely identifies the image loss caused by metal artifacts and can be applied to monitoring bone maturation around orthopedic implants. In addition, by observing the new bone formation, a new principle and timetable for an implant osseointegrated with bone can be established and a new type of implant fixture or surface treatment can be evaluated using this system.

Indexed as

Dental ImplantsOsseointegrationAnimalsMaxillaOsteogenesisProstheses and ImplantsRatsRats, Sprague-DawleyTitaniumDental ImplantsTitaniumartifactgold nanoparticlehydroxyapatitenear-infrared rayosteoblast

Identifiers

PMID36902462
PMCPMC10003657

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