Evidence map›Paper›PMID 36902441›Full record

ReviewInternational journal of molecular sciences2023

Revisiting Host-Pathogen Interactions in Cystic Fibrosis Lungs in the Era of CFTR Modulators.

Carla M P Ribeiro, Matthew G Higgs, Marianne S Muhlebach, Matthew C Wolfgang, Monica Borgatti, Ilaria Lampronti, Giulio Cabrini

Full text readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Biofilm Formation ofMicroorganisms · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025
    Article
  11. Changing profile of bacterial infection and microbiome in cystic fibrosis: when to use antibiotics in the era of CFTR-modulator therapy.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Frontiers in immunology · 2024
    Review
  19. Frontiers in cellular and infection microbiology · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carla M P RibeiroMarsico Lung Institute/Cystic Fibrosis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-5247-7060
Matthew G HiggsMarsico Lung Institute/Cystic Fibrosis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-5460-4980
Marianne S MuhlebachMarsico Lung Institute/Cystic Fibrosis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Matthew C WolfgangMarsico Lung Institute/Cystic Fibrosis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-4534-6470
Monica BorgattiDepartment of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-8470-2496
Ilaria LamprontiDepartment of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-1972-7766
Giulio CabriniDepartment of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy.

Funding

Pre-Clinical Evaluation of IRE1beta as a Novel Therapeutic Target for Cystic Fibrosis Airway Mucus ProductionR01HL155261 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RIBEIRO, CARLA MARIA PEDROSA · 2021 to 2024
$1.8M
Cystic Fibrosis Foundation MUHLEB17A0Cystic Fibrosis Foundation MUHLEB 22A0Cystic Fibrosis Foundation RIBEIR20P0Cystic Fibrosis Foundation WOLFGA19G0Cystic Fibrosis Research Foundation FFC 10/2022Cystic Fibrosis Research Foundation FFC 7/2019NHLBI NIH HHS R01 HL155261NIH HHS 1 R01 HL155261
6 · The paper itself

Abstract

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators, a new series of therapeutics that correct and potentiate some classes of mutations of the CFTR, have provided a great therapeutic advantage to people with cystic fibrosis (pwCF). The main hindrances of the present CFTR modulators are related to their limitations in reducing chronic lung bacterial infection and inflammation, the main causes of pulmonary tissue damage and progressive respiratory insufficiency, particularly in adults with CF. Here, the most debated issues of the pulmonary bacterial infection and inflammatory processes in pwCF are revisited. Special attention is given to the mechanisms favoring the bacterial infection of pwCF, the progressive adaptation of

Indexed as

Cystic FibrosisStaphylococcal InfectionsAdultCystic Fibrosis Transmembrane Conductance RegulatorHost-Pathogen InteractionsHumansLungPseudomonas aeruginosaCFTR protein, humanCystic Fibrosis Transmembrane Conductance Regulatorairway epitheliaairway infectionairway inflammationCFTR modulatorscystic fibrosisPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID36902441
PMCPMC10003689

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read19
identifiers read2
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.