Evidence map›Paper›PMID 36902408›Full record

ArticleInternational journal of molecular sciences2023

Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma.

Tien-Li Lan, Chun-Fu Lin, Yi-Yen Lee, Ko-Han Lin, Feng-Chi Chang, Shih-Chieh Lin, Jia-Cheng Lee, Fong-In Chou, Jinn-Jer Peir, Hong-Ming Liu and 2 more

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Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  6. Hypo-segmentation ofEJNMMI research · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Cobaltabis(Dicarbollide) [Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  11. Article
  12. Review
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tien-Li LanDepartment of Heavy Particles and Radiation Oncology, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan.ORCID 0000-0002-0972-713X
Chun-Fu LinDivision of General Neurosurgery, Taipei Veterans General Hospital Neurosurgical Department, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan.
Yi-Yen LeeDivision of General Neurosurgery, Taipei Veterans General Hospital Neurosurgical Department, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan.ORCID 0000-0003-3709-885X
Ko-Han LinDepartment of Nuclear Medicinel, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan.
Feng-Chi ChangDivision of Neuroradiology, Department of Radiology, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan.
Shih-Chieh LinDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan.
Jia-Cheng LeeDepartment of Heavy Particles and Radiation Oncology, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan.
Fong-In ChouInstitute of Nuclear Engineering and Science, National Tsing Hua University, No.101, Sec 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.
Jinn-Jer PeirInstitute of Nuclear Engineering and Science, National Tsing Hua University, No.101, Sec 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.ORCID 0000-0002-9196-4897
Hong-Ming LiuInstitute of Nuclear Engineering and Science, National Tsing Hua University, No.101, Sec 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.
Pei-Fan MuInstitute of Clinical Nursing, National Yang Ming Chiao Tung University, No.155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan.
Yi-Wei ChenDepartment of Heavy Particles and Radiation Oncology, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou Dist., Taipei City 11217, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. We also introduce and support the effectiveness and safety of BNCT as an alternative salvage treatment for recurrent meningiomas.

Indexed as

Boron Neutron Capture TherapyBrain NeoplasmsMeningeal NeoplasmsMeningiomaAdultBoronBoron CompoundsHumansBoronBoron Compoundsatypical meningiomaBoron Neutron Capture Therapy (BNCT)targeted radiotherapy

Identifiers

PMID36902408
PMCPMC10003570

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.