Evidence map›Paper›PMID 36902385›Full record

ReviewInternational journal of molecular sciences2023

Targeting Mitochondrial Metabolic Reprogramming as a Potential Approach for Cancer Therapy.

Liufeng Zhang, Yuancheng Wei, Shengtao Yuan, Li Sun

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In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Liufeng ZhangJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 211198, China.
Yuancheng WeiJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 211198, China.
Shengtao YuanJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 211198, China.
Li SunJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 211198, China.

Funding

National Nature Science Foundation of China 82272668
6 · The paper itself

Abstract

Abnormal energy metabolism is a characteristic of tumor cells, and mitochondria are important components of tumor metabolic reprogramming. Mitochondria have gradually received the attention of scientists due to their important functions, such as providing chemical energy, producing substrates for tumor anabolism, controlling REDOX and calcium homeostasis, participating in the regulation of transcription, and controlling cell death. Based on the concept of reprogramming mitochondrial metabolism, a range of drugs have been developed to target the mitochondria. In this review, we discuss the current progress in mitochondrial metabolic reprogramming and summarized the corresponding treatment options. Finally, we propose mitochondrial inner membrane transporters as new and feasible therapeutic targets.

Indexed as

MitochondriaNeoplasmsEnergy MetabolismHumansMitochondrial MembranesOxidation-Reductioncancerdrug developmentmetabolic reprogrammingmitochondria

Identifiers

PMID36902385
PMCPMC10003438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.