Evidence map›Paper›PMID 36902377›Full record

ArticleInternational journal of molecular sciences2023

Association of SNPs in the PAI1 Gene with Disease Recurrence and Clinical Outcome in Bladder Cancer.

Kaoru Murakami, Hideki Furuya, Kanani Hokutan, Steve Goodison, Ian Pagano, Runpu Chen, Cheng-Huang Shen, Michael W Y Chan, Chi Fai Ng, Takashi Kobayashi and 8 more

Open access · goldFull text read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 4 countries.

Kaoru MurakamiSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0002-4226-3867
Hideki FuruyaSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0002-9536-8662
Kanani HokutanClinical and Translational Research Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Steve GoodisonDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL 32224, USA.
Ian PaganoPopulation Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.ORCID 0000-0002-6248-0113
Runpu ChenDepartment of Microbiology and Immunology, The State University of New York at Buffalo, Buffalo, NY 14260, USA.
Cheng-Huang ShenDepartment of Urology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600, Taiwan.ORCID 0000-0003-0058-5128
Michael W Y ChanDepartment of Biomedical Sciences, National Chung Cheng University, Chia-Yi 621, Taiwan.ORCID 0000-0003-1431-322X
Chi Fai NgSH Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0002-1723-9646
Takashi KobayashiDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.ORCID 0000-0003-1069-2816
Osamu OgawaDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Makito MiyakeDepartment of Urology, Nara Medical University, Nara 6348522, Japan.ORCID 0000-0001-9503-7356
Mark ThornquistFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Yoshiko ShimizuClinical and Translational Research Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Kazukuni HayashiClinical and Translational Research Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Zhangwei WangPopulation Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Herbert YuPopulation Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Charles J RosserSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.ORCID 0000-0002-6052-4223
University of Hawaiʻi at Mānoa · USCedars-Sinai Medical Center · USKyoto University · JPChia-Yi Christian Hospital · TWChinese University of Hong Kong · HKFred Hutch Cancer Center · USMayo Clinic in Florida · USNara Medical University · JPNational Chung Cheng University · TWUniversity at Buffalo, State University of New York · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
VALIDATION OF A MULTIPLEXED ASSAY FOR BLADDER CANCER DIAGNOSISR01CA198887 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI ROSSER, CHARLES J · 2016 to 2025
$6.8M
Training in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8M
APPLICATION OF A MULTIPLEXED IMMUNOASSAY FOR THE DETECTION OF BLADDER CANCERUH3CA271377 · NCI · CEDARS-SINAI MEDICAL CENTER · PI ROSSER, CHARLES J · 2022 to 2024
$1.2M
Humanized anti-CXCL1 antibody for bladder cancer therapeuticsR21CA263230 · NCI · CEDARS-SINAI MEDICAL CENTER · PI FURUYA, HIDEKI · 2021 to 2022
$423k
NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA198887NCI NIH HHS R01CA198887NCI NIH HHS R21 CA263230NCI NIH HHS R21CA263230NCI NIH HHS UH3 CA271377NCI NIH HHS UH3CA271377NHLBI NIH HHS T32 HL115505
6 · The paper itself

Abstract

purposeBladder cancer (BCa) is one of the most common cancer types worldwide and is characterized by a high rate of recurrence. In previous studies, we and others have described the functional influence of plasminogen activator inhibitor-1 (PAI1) in bladder cancer development. While polymorphisms in

methodsIn this study, we evaluated the mutational status of PAI1 in a series of independent cohorts, comprised of a total of 660 subjects.

resultsSequencing analyses identified two clinically relevant 3' untranslated region (UTR) single nucleotide polymorphisms (SNPs) in

conclusionFurther investigation of the prevalence and potential downstream influence of these SNPs in bladder cancer is warranted.

Indexed as

Plasminogen Activator Inhibitor 1Polymorphism, Single NucleotideUrinary Bladder NeoplasmsHumansNeoplasm Recurrence, LocalPlasminogen Activator Inhibitor 1SERPINE1 protein, human3′ UTR SNPapoptosisbladder cancerClaspinplasminogen activator inhibitor-1recurrencesurvival

Identifiers

PMID36902377
PMCPMC10003630
OpenAlexW4323314307

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read132
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.