Evidence map›Paper›PMID 36902353›Full record

ArticleInternational journal of molecular sciences2023

The CaSR Modulator NPS-2143 Reduced UV-Induced DNA Damage in Skh:hr1 Hairless Mice but Minimally Inhibited Skin Tumours.

Chen Yang, Mark Stephen Rybchyn, Warusavithana Gunawardena Manori De Silva, Jim Matthews, Katie Marie Dixon, Andrew J A Holland, Arthur David Conigrave, Rebecca Sara Mason

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In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Cyclic AMP-regulatory element-binding protein: a novel UV-targeted transcription factor in skin cancer.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chen YangSchool of Medical Sciences and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia.
Mark Stephen RybchynSchool of Medical Sciences and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-4336-6227
Warusavithana Gunawardena Manori De SilvaSchool of Medical Sciences and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia.
Jim MatthewsSydney Informatics Hub, University of Sydney, Sydney, NSW 2008, Australia.
Katie Marie DixonSchool of Medical Sciences and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia.
Andrew J A HollandDouglas Cohen Department of Paediatric Surgery, The Children's Hospital at Westmead Clinical School, The Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2145, Australia.ORCID 0000-0003-3745-8704
Arthur David ConigraveSchool of Life and Environmental Sciences, Charles Perkins Centre (D17), University of Sydney, Sydney, NSW 2006, Australia.
Rebecca Sara MasonSchool of Medical Sciences and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0003-1534-9697

Funding

National Health and Medical Research Council APP1070688
6 · The paper itself

Abstract

The calcium-sensing receptor (CaSR) is an important regulator of epidermal function. We previously reported that knockdown of the CaSR or treatment with its negative allosteric modulator, NPS-2143, significantly reduced UV-induced DNA damage, a key factor in skin cancer development. We subsequently wanted to test whether topical NPS-2143 could also reduce UV-DNA damage, immune suppression, or skin tumour development in mice. In this study, topical application of NPS-2143 (228 or 2280 pmol/cm

Indexed as

Receptors, Calcium-SensingSkin NeoplasmsAnimalsDNA DamageFemaleHumansMiceMice, HairlessPyrimidine DimersSkinUltraviolet RaysCASR protein, humanPyrimidine DimersReceptors, Calcium-Sensing1a,25-dihydroxyvitamin D3 (1,25D)8-hydroxy-2′–deoxyguanosine (8-OHdG)calcium sensing receptor (CaSR)cyclic AMP response element binding factor (CREB)cyclobutane pyrimidine dimer (CPD)photocarcinogenesisphotoprotectionsquamous cell carcinoma (SCC)ultraviolet radiation (UV)

Identifiers

PMID36902353
PMCPMC10002576

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read32
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.