Evidence map›Paper›PMID 36902351›Full record

ArticleInternational journal of molecular sciences2023

New Insights into the Identification of Metabolites and Cytokines Predictive of Outcome for Patients with Severe SARS-CoV-2 Infection Showed Similarity with Cancer.

Susan Costantini, Gabriele Madonna, Elena Di Gennaro, Francesca Capone, Palmina Bagnara, Mariaelena Capone, Silvia Sale, Carmine Nicastro, Lidia Atripaldi, Giuseppe Fiorentino and 5 more

Full text read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. Review
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Susan CostantiniExperimental Pharmacology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0002-7538-4657
Gabriele MadonnaMelanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0001-9395-3190
Elena Di GennaroExperimental Pharmacology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0001-6223-7845
Francesca CaponeExperimental Pharmacology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.
Palmina BagnaraExperimental Pharmacology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.
Mariaelena CaponeMelanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0002-1352-2532
Silvia SaleUOC Biochimica Clinica, AORN Ospedali dei Colli-Monaldi-Cotugno-CTO, 80131 Napoli, Italy.
Carmine NicastroUOC Biochimica Clinica, AORN Ospedali dei Colli-Monaldi-Cotugno-CTO, 80131 Napoli, Italy.ORCID 0000-0002-0399-3576
Lidia AtripaldiDipartimento di Scienze Mediche Traslazionali, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Giuseppe FiorentinoUOC Fisiopatologia e Riabilitazione Respiratoria, AORN Ospedali dei Colli-Monaldi-Cotugno-CTO, 80131 Napoli, Italy.ORCID 0000-0002-2523-9769
Roberto ParrellaUOC Malattie Infettive ad Indirizzo Respiratorio, AORN Ospedali dei Colli-Monaldi-Cotugno-CTO, 80131 Napoli, Italy.
Vincenzo MontesarchioUOC Oncologia, AORN Ospedali dei Colli-Monaldi-Cotugno-CTO, 80131 Napoli, Italy.
Luigi AtripaldiUOC Biochimica Clinica, AORN Ospedali dei Colli-Monaldi-Cotugno-CTO, 80131 Napoli, Italy.
Paolo A AsciertoMelanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0002-8322-475X
Alfredo BudillonScientific Directorate, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Napoli, Italy.ORCID 0000-0002-6330-6053

Funding

Italian Ministry of Health-Ricerca Corrente Funds-Istituto Nazionale Tumori G. Pascale Progetti Linea1/4 (to S.C.) and Linea 2/2 (to A.B.)POR CAMPANIA FESR 2014/2020 Progetto: "Caratterizzazione biomolecolare del virus SARS-COV-2 e dei cofattori dell'infiammazione implicati nella patogenesi del COVID-19" CUP: H64I20000300002 (to P.A.A.)
6 · The paper itself

Abstract

SARS-CoV-2 infection is characterized by several clinical manifestations, ranging from the absence of symptoms to severe forms that necessitate intensive care treatment. It is known that the patients with the highest rate of mortality develop increased levels of proinflammatory cytokines, called the "cytokine storm", which is similar to inflammatory processes that occur in cancer. Additionally, SARS-CoV-2 infection induces modifications in host metabolism leading to metabolic reprogramming, which is closely linked to metabolic changes in cancer. A better understanding of the correlation between perturbed metabolism and inflammatory responses is necessary. We evaluated untargeted plasma metabolomics and cytokine profiling via

Indexed as

COVID-19NeoplasmsCytokinesHumansLactatesSARS-CoV-2CytokinesLactatescancercytokinesmetabolitespatient outcomeSARS-CoV-2 infection

Identifiers

PMID36902351
PMCPMC10003544

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read6
measurements read16
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.