ArticleInternational journal of molecular sciences2023
Cardiomyocyte Apoptosis Is Associated with Contractile Dysfunction in Stem Cell Model of
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Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 14 citations in OpenAlex.
- Genetic vulnerability and dynamic mechanical stress synergistically drive sarcomere failure in human iPSC-derived cardiomyocytes.Materials today. Bio · 2026Article
- Biomechanical stress unmasks a fibroblast-dependent hypercontractile-disarray phenotype in MYBPC3 truncation HCM.APL bioengineering · 2026Article
- Identification of Centrosome Duplication-Related Biomarkers in Hypertrophic Cardiomyopathy Through Integrative Multi-Omics, Single-Cell Transcriptomics, and Experimental Validation.Journal of the American Heart Association · 2026Article
- Functional and Expression Studies of iPSC-Derived Cardiomyocytes Carrying a Novel HCM-AssociatedGenes · 2026Article
- High-Throughput Methods for Variant Functional Assessment in Cardiac Disease.Circulation. Genomic and precision medicine · 2026Review
- Dystrophin Loss in Engineered Heart Tissues Recapitulates Clinically Relevant Aspects of Dystrophic Cardiomyopathy.Journal of biomechanical engineering · 2026Article
- Human Cardiac Organoids: Advances and Prospects from Construction to Preclinical Drug Evaluation.Cells · 2025Review
- Suspended Tissue Open Microfluidic Patterning (STOMP).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Suspended Tissue Open Microfluidic Patterning (STOMP).bioRxiv : the preprint server for biology · 2025Article
- Induced pluripotent stem cell-derived cardiomyocyte in vitro models: benchmarking progress and ongoing challenges.Nature methods · 2025Review
- Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling.Science advances · 2024Article
- Three-dimensional cardiac models: a pre-clinical testing platform.Biochemical Society transactions · 2024Review
- Multiplexed Functional Assessments ofCirculation. Genomic and precision medicine · 2024Article
- The new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish.Medical review (2021) · 2024Review
- Engineered Heart Tissues for Standard 96-Well Tissue Culture Plates.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Beyond autophagic flux: selective autophagy adaptors and cargo prioritization in cardiac disease.Cardiology plusReview
Corrections and comments
- Update of
Authors and funding
9 authors at 1 institution in 1 country.
Alexander M LoibenInstitute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA 98109, USA.
Wei-Ming ChienInstitute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA 98109, USA.
Clayton E FriedmanInstitute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0003-4211-886X
Leslie S-L ChaoInstitute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA 98109, USA.
Gerhard WeberDepartment of Medicine/Cardiology, University of Washington, Seattle, WA 98109, USA.
Alex GoldsteinInstitute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA 98109, USA.
Nathan J SniadeckiInstitute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA 98109, USA.
Charles E MurryInstitute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0003-3862-6773
Kai-Chun YangInstitute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0001-5429-6853
University of Washington · US
Funding
Technology to understand genetic variant effects in contextRM1HG010461 · NHGRI · UNIVERSITY OF WASHINGTON · PI Douglas M Fowler, Bruce Colston Trapnell · 2019 to 2026
$18.9MUW Center for Translational Muscle Research (Overall Application)P30AR074990 · NIAMS · UNIVERSITY OF WASHINGTON · PI MICHAEL REGNIER · 2019 to 2026
$7.5MMechanotransduction by Melusin in Cardiac HypertrophyR01HL149734 · NHLBI · UNIVERSITY OF WASHINGTON · PI SNIADECKI, NATHAN JOHN · 2020 to 2023
$2.1MDissecting the mechanisms of how MYH7 S2 mutations lead to genetic hypertrophic cardiomyopathyF32HL164108 · NHLBI · UNIVERSITY OF WASHINGTON · PI LOIBEN, ALEXANDER · 2022 to 2024
$213kDissecting the mechanism of how dominant negative MYH7 mutations lead to genetic cardiomyopathiesIK2BX004642 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI YANG, KAI-CHUN DANIEL · 2020 to 2024
–BLRD VA IK2 BX004642NHGRI NIH HHS RM1 HG010461NHLBI NIH HHS F32 HL164108NHLBI NIH HHS R01 HL149734NIAMS NIH HHS P30 AR074990
Abstract
Missense mutations in myosin heavy chain 7 (
Indexed as
Cardiomyopathy, HypertrophicInduced Pluripotent Stem CellsAdultApoptosisCardiac MyosinsHumansMutationMyocardial ContractionMyocytes, CardiacMyosin Heavy ChainsTumor Suppressor Protein p53Cardiac MyosinsMYH7 protein, humanMyosin Heavy ChainsTumor Suppressor Protein p53apoptosiscontractile dysfunctiondilated cardiomyopathyengineered heart tissuehypertrophic cardiomyopathyinduced pluripotent stem cellsMYH7p53
Identifiers
What OpenQuestion holds
Textfull text, public
LicenceCC BY
measurements read137
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.