Evidence map›Paper›PMID 36902266›Full record

SynthesisInternational journal of molecular sciences2023

The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases.

Marcin Wróblewski, Joanna Wróblewska, Jarosław Nuszkiewicz, Marta Pawłowska, Roland Wesołowski, Alina Woźniak

Full text readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Assessment of essential and toxic trace element imbalances in hypothyroid patients with and without levothyroxine therapy: a case-control study.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. The role of nutrition on thyroid health and disease: myths and facts.Journal of endocrinological investigation · 2026
    Review
  3. Article
  4. [Association between mixed metal element exposure and the risk of thyroid carcinoma: a case-control study].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Cardiovascular Findings and Effects of Caffeine on Experimental Hypothyroidism.Endocrine, metabolic & immune disorders drug targets · 2025
    Article
  16. Review
  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcin WróblewskiDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, Poland.ORCID 0000-0002-7887-132X
Joanna WróblewskaDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, Poland.ORCID 0000-0002-8188-8296
Jarosław NuszkiewiczDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, Poland.ORCID 0000-0003-1378-5065
Marta PawłowskaDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, Poland.ORCID 0000-0003-1640-9196
Roland WesołowskiDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, Poland.ORCID 0000-0003-2673-8313
Alina WoźniakDepartment of Medical Biology and Biochemistry, Collegium Medicum, Nicolaus Copernicus University, 85-092 Bydgoszcz, Poland.ORCID 0000-0002-4492-4796

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired levels of selenium (Se), zinc (Zn), copper (Cu), iron (Fe), manganese (Mn) and iodine (I) in the organism may adversely affect the thyroid endocrine system. These trace elements play a role in the fight against oxidative stress as components of enzymes. Oxidative-antioxidant imbalance is considered a possible factor in many pathological conditions, including various thyroid diseases. In the available literature, there are few scientific studies showing a direct correlation of the effect of supplementation of trace elements on slowing down or preventing the occurrence of thyroid diseases in combination with the improvement of the antioxidant profile, or through the action of these elements as antioxidants. Among the available studies, it has been shown that an increase in lipid peroxidation levels and a decrease in the overall antioxidant defense status occur during such thyroid diseases as thyroid cancer, Hashimoto's thyroiditis and dysthyroidism. In studies in which trace elements were supplemented, the following were observed: a decrease in the level of malondialdehyde after supplementation with Zn during hypothyroidism and reduction in the malondialdehyde level after Se supplementation with a simultaneous increase in the total activity status and activity of antioxidant defense enzymes in the course of autoimmune thyroiditis. This systematic review aimed to present the current state of knowledge about the relationship between trace elements and thyroid diseases in terms of oxidoreductive homeostasis.

Indexed as

SeleniumThyroid DiseasesTrace ElementsAntioxidantsCopperHomeostasisHumansMalondialdehydeZincAntioxidantsCopperMalondialdehydeSeleniumTrace ElementsZincoxidative stressthyroid diseasestrace elements

Identifiers

PMID36902266
PMCPMC10003705

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.