Evidence map›Paper›PMID 36902261›Full record

ArticleInternational journal of molecular sciences2023

Highly Specific Detection of Oxytocin in Saliva.

Muhit Rana, Nimet Yildirim, Nancy E Ward, Stephanie P Vega, Michael J Heffernan, Avni A Argun

Open access · goldFull text read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Close encounters with oxytocin.Comprehensive psychoneuroendocrinology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Muhit RanaGiner, Inc., 89 Rumford Avenue, Newton, MA 02466, USA.
Nimet YildirimGiner, Inc., 89 Rumford Avenue, Newton, MA 02466, USA.
Nancy E WardRaptamer Discovery Group, 3900 Essex Lane, Suite 575, Houston, TX 77027, USA.
Stephanie P VegaRaptamer Discovery Group, 3900 Essex Lane, Suite 575, Houston, TX 77027, USA.
Michael J HeffernanRaptamer Discovery Group, 3900 Essex Lane, Suite 575, Houston, TX 77027, USA.
Avni A ArgunGiner, Inc., 89 Rumford Avenue, Newton, MA 02466, USA.ORCID 0000-0002-0423-7633
Giner (United States) · USRaptamer Discovery Group (United States) · US

Funding

X-Aptamer Selection KitR44GM108110 · NIGMS · AM BIOTECHNOLOGIES, LLC · PI LAM, CURTIS HONMING, WARD, NANCY ELAINE · 2015 to 2016
$1.3M
X-Aptamer Selection KitR43GM108110 · NIGMS · AM BIOTECHNOLOGIES, LLC · PI LAM, CURTIS HONMING, WARD, NANCY ELAINE · 2013 to 2014
$650k
Non-Invasive, Highly Specific Detection of Oxytocin in Biological FluidsR41HD088137 · NICHD · GINER, INC. · PI ARGUN, AVNI A · 2016 to 2016
$225k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R41HD088137NICHD NIH HHS R41 HD088137NIGMS NIH HHS GM108110NIGMS NIH HHS R43 GM108110NIGMS NIH HHS R44 GM108110
6 · The paper itself

Abstract

Oxytocin is a peptide neurophysin hormone made up of nine amino acids and is used in induction of one in four births worldwide (more than 13 percent in the United States). Herein, we have developed an antibody alternative aptamer-based electrochemical assay for real-time and point-of-care detection of oxytocin in non-invasive saliva samples. This assay approach is rapid, highly sensitive, specific, and cost-effective. Our aptamer-based electrochemical assay can detect as little as 1 pg/mL of oxytocin in less than 2 min in commercially available pooled saliva samples. Additionally, we did not observe any false positive or false negative signals. This electrochemical assay has the potential to be utilized as a point-of-care monitor for rapid and real-time oxytocin detection in various biological samples such as saliva, blood, and hair extracts.

Indexed as

Aptamers, NucleotideElectrochemical TechniquesOxytocinSalivaHumansPoint-of-Care SystemsAptamers, NucleotideOxytocinaptamerelectrochemicaloxytocinpeptide detectionsalivasensor

Identifiers

PMID36902261
PMCPMC10003004
OpenAlexW4322770388

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read17
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.