ReviewInternational journal of molecular sciences2023
Are the Properties of Bone Marrow-Derived Mesenchymal Stem Cells Influenced by Overweight and Obesity?
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Review
- Diet and Lipidomics Mediated Regulation of Mesenchymal Stem Cell Function: Diet, Omics and Stem Cell Connection.Biomolecules · 2026Review
- Independent and synergistic associations of cumulative body roundness index and its variability with fragility fracture risk.Lipids in health and disease · 2026Article
- Impact of metabolic score for visceral fat on bone health in adolescent population: a cross-sectional study perspective.Frontiers in nutrition · 2026Article
- Review
- Weight-adjusted waist index associated with bone mineral density in rheumatoid arthritis patients: a cross-sectional study.Clinical rheumatology · 2025Article
- The saturation effect of a body shape index on lumbar bone mineral density in US adults: Findings from a nationwide survey.PloS one · 2025Article
- Association between A body shape index and bone mineral density in middle-aged and elderly adults: a retrospective analysis of NHANES 2005-2018.Frontiers in endocrinology · 2025Article
- Association of a body shape index with femur bone mineral density among older adults: NHANES 2007-2018.Archives of osteoporosis · 2024Article
- Central obesity may affect bone development in adolescents: association between abdominal obesity index ABSI and adolescent bone mineral density.BMC endocrine disorders · 2024Article
- Effect of metabolically divergent pig breeds and tissues on mesenchymal stem cell expression patterns during adipogenesis.BMC genomics · 2024Article
- Exploring the Interplay between Bone Marrow Stem Cells and Obesity.International journal of molecular sciences · 2024Review
- Association between waist-to-height ratio and osteoporosis in the National Health and Nutrition Examination Survey: a cross-sectional study.Frontiers in medicine · 2024Article
- Negative association between Body Roundness Index and bone mineral density: insights from NHANES.Frontiers in nutrition · 2024Article
- Synergic Action of Systemic Risedronate and Local Rutherpy in Peri-implantar Repair of Ovariectomized Rats: Biomechanical and Molecular Analysis.International journal of molecular sciences · 2023Article
- Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition.Metabolites · 2023Review
- A cross-sectional study from NHANES found a positive association between obesity with bone mineral density among postmenopausal women.BMC endocrine disorders · 2023Article
- The relationship between weight-adjusted-waist index and total bone mineral density in adults aged 20-59.Frontiers in endocrinology · 2023Article
- The association between weight-adjusted-waist index and total bone mineral density in adolescents: NHANES 2011-2018.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow-derived mesenchymal stem cells (BMSCs) are promising candidates for cell-based therapies. Growing evidence has indicated that overweight/obesity can change the bone marrow microenvironment, which affects some properties of BMSCs. As the overweight/obese population rapidly increases, they will inevitably become a potential source of BMSCs for clinical application, especially when receiving autologous BMSC transplantation. Given this situation, the quality control of these cells has become particularly important. Therefore, it is urgent to characterize BMSCs isolated from overweight/obese bone marrow environments. In this review, we summarize the evidence of the effects of overweight/obesity on the biological properties of BMSCs derived from humans and animals, including proliferation, clonogenicity, surface antigen expression, senescence, apoptosis, and trilineage differentiation, as well as the underlying mechanisms. Overall, the conclusions of existing studies are not consistent. Most studies demonstrate that overweight/obesity can influence one or more characteristics of BMSCs, while the involved mechanisms are still unclear. Moreover, insufficient evidence proves that weight loss or other interventions can rescue these qualities to baseline status. Thus, further research should address these issues and prioritize developing methods to improve functions of overweight- or obesity-derived BMSCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.