Evidence map›Paper›PMID 36902219›Full record

ArticleInternational journal of molecular sciences2023

Phosphorylated Peptide Derived from the Myosin Phosphatase Target Subunit Is a Novel Inhibitor of Protein Phosphatase-1.

Zoltán Kónya, István Tamás, Bálint Bécsi, Beáta Lontay, Mária Raics, István Timári, Katalin E Kövér, Ferenc Erdődi

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In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zoltán KónyaDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
István TamásDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-1020-2859
Bálint BécsiDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Beáta LontayDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-2545-8275
Mária RaicsDepartment of Inorganic and Analytical Chemistry, Faculty of Natural Science and Technology, University of Debrecen, H-4032 Debrecen, Hungary.
István TimáriDepartment of Organic Chemistry, Faculty of Natural Science and Technology, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-0504-6967
Katalin E KövérDepartment of Inorganic and Analytical Chemistry, Faculty of Natural Science and Technology, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0001-5020-4456
Ferenc ErdődiDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
University of Debrecen · HU

Funding

Hungarian Academy of Sciences János Bolyai Research Scholarship (BO/00372/20/7) to I. T.National Research, Development and Innovation Office K129104 (to F. E)National Research, Development and Innovation Office K143533 to (B. L.)National Research, Development and Innovation Office NN128368 to (K.E.K.)
6 · The paper itself

Abstract

Identification of specific protein phosphatase-1 (PP1) inhibitors is of special importance regarding the study of its cellular functions and may have therapeutic values in diseases coupled to signaling processes. In this study, we prove that a phosphorylated peptide of the inhibitory region of myosin phosphatase (MP) target subunit (MYPT1), R

Indexed as

Enzyme InhibitorsPhosphopeptidesProtein Phosphatase 1Myosin-Light-Chain PhosphatasePhosphorylationPhosphoserinePhosphothreonineEnzyme InhibitorsMyosin-Light-Chain PhosphatasePhosphopeptidesPhosphoserinePhosphothreonineProtein Phosphatase 1molecular dockingmyosin phosphatase (MP)myosin phosphatase target subunit-1 (MYPT1)MYPT1 inhibitory peptide (P-Thr696-MYPT1690−701)protein phosphatase-1 (PP1)saturation transfer difference NMR

Identifiers

PMID36902219
PMCPMC10003451
OpenAlexW4322770772

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read31
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.