Evidence map›Paper›PMID 36902158›Full record

ArticleInternational journal of molecular sciences2023

An Early and Sustained Inflammatory State Induces Muscle Changes and Establishes Obesogenic Characteristics in Wistar Rats Exposed to the MSG-Induced Obesity Model.

Matheus Felipe Zazula, Diego Francis Saraiva, João Lucas Theodoro, Mônica Maciel, Eliel Vieira Dos Santos Sepulveda, Bárbara Zanardini de Andrade, Mariana Laís Boaretto, Jhyslayne Ignácia Hoff Nunes Maciel, Gabriela Alves Bronczek, Gabriela Moreira Soares and 6 more

Full text read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Investigating the Chemical Composition ofFoods (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Matheus Felipe ZazulaLaboratório de Plasticidade Morfofuncional, Departamento de Biologia Celular, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba 81530-000, Paraná, Brazil.ORCID 0000-0002-4760-5977
Diego Francis SaraivaLaboratório de Plasticidade Morfofuncional, Departamento de Biologia Celular, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba 81530-000, Paraná, Brazil.
João Lucas TheodoroLaboratório de Plasticidade Morfofuncional, Departamento de Biologia Celular, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba 81530-000, Paraná, Brazil.ORCID 0000-0002-6192-6347
Mônica MacielLaboratório de Plasticidade Morfofuncional, Departamento de Biologia Celular, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba 81530-000, Paraná, Brazil.
Eliel Vieira Dos Santos SepulvedaLaboratório de Plasticidade Morfofuncional, Departamento de Biologia Celular, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba 81530-000, Paraná, Brazil.
Bárbara Zanardini de AndradeLaboratório de Biologia Estrutural e Funcional, Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná, Cascavel 85819-110, Paraná, Brazil.ORCID 0000-0003-0909-8668
Mariana Laís BoarettoLaboratório de Estudo de Lesões e Recursos Fisioterapêuticos, Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná, Cascavel 85819-110, Paraná, Brazil.
Jhyslayne Ignácia Hoff Nunes MacielLaboratório de Estudo de Lesões e Recursos Fisioterapêuticos, Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná, Cascavel 85819-110, Paraná, Brazil.
Gabriela Alves BronczekCentro de Pesquisa em Obesidade e Comorbidades, Departamento de Biologia Estrutural e Funcional, Universidade Estadual de Campinas, Campinas 13083-970, São Paulo, Brazil.
Gabriela Moreira SoaresCentro de Pesquisa em Obesidade e Comorbidades, Departamento de Biologia Estrutural e Funcional, Universidade Estadual de Campinas, Campinas 13083-970, São Paulo, Brazil.
Sara Cristina Sagae SchneiderLaboratório de Fisiologia Endócrina e Metabolismo, Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná, Cascavel 85819-110, Paraná, Brazil.
Gladson Ricardo Flor BertoliniLaboratório de Estudo de Lesões e Recursos Fisioterapêuticos, Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná, Cascavel 85819-110, Paraná, Brazil.ORCID 0000-0003-0565-2019
Márcia Miranda TorrejaisLaboratório Experimental de Morfologia, Centro de Ciências Médicas e Farmacêuticas, Universidade Estadual do Oeste do Paraná, Cascavel 85819-110, Paraná, Brazil.
Lucinéia Fátima Chasko RibeiroLaboratório de Biologia Estrutural e Funcional, Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná, Cascavel 85819-110, Paraná, Brazil.
Luiz Claudio FernandesLaboratório de Metabolismo Celular, Departamento de Fisiologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba 81530-000, Paraná, Brazil.
Katya NaliwaikoLaboratório de Plasticidade Morfofuncional, Departamento de Biologia Celular, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba 81530-000, Paraná, Brazil.

Funding

Fundação Araucária 016/2016
6 · The paper itself

Abstract

The model of obesity induced by monosodium glutamate cytotoxicity on the hypothalamic nuclei is widely used in the literature. However, MSG promotes persistent muscle changes and there is a significant lack of studies that seek to elucidate the mechanisms by which damage refractory to reversal is established. This study aimed to investigate the early and chronic effects of MSG induction of obesity upon systemic and muscular parameters of Wistar rats. The animals were exposed to MSG subcutaneously (4 mg·g

Indexed as

ObesitySodium GlutamateAnimalsFibrosisMusclesRatsRats, WistarSodium Glutamatedistress oxidativehyperinsulinemiametabolic syndromemonosodium glutamatepro-inflammatory profileskeletal muscle fiber types

Identifiers

PMID36902158
PMCPMC10003260

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.