Evidence map›Paper›PMID 36902150›Full record

ArticleInternational journal of molecular sciences2023

Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin.

Justin N Williams, Mavis Irwin, Yong Li, Anuradha Valiya Kambrath, Brett T Mattingly, Sheel Patel, Mizuho Kittaka, Rebecca N Collins, Nicholas A Clough, Emma H Doud and 8 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Justin N WilliamsDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Mavis IrwinDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Yong LiDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Anuradha Valiya KambrathDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Brett T MattinglyDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Sheel PatelDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Mizuho KittakaIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Rebecca N CollinsDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Nicholas A CloughDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Emma H DoudDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Amber L MosleyDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Teresita BellidoDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Angela BruzzanitiIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Lilian I PlotkinDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-9537-4544
Jonathan C TrinidadDepartment of Chemistry, Biological Mass Spectrometry Facility, Indiana University, Bloomington, IN 47405, USA.
William R ThompsonIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-7022-585X
Lynda F BonewaldDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Uma SankarDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-9406-5686
Indiana University School of MedicineIndiana University Bloomington · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Comprehensive Training Program in Musculoskeletal ResearchT32AR065971 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI ALEXANDER G ROBLING · 2015 to 2026
$4.4M
CaMKK2 Signaling in OsteoarthritisR01AR076477 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SANKAR, UMA · 2020 to 2024
$3.0M
Osteocyte Mechanotransduction and the Gabapentin-Sensitive Matrix-Channel Tethering ComplexR01AR074473 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI THOMPSON, WILLIAM ROY · 2018 to 2023
$2.8M
CaMKK2 Inhibition as a Dual-Action Bone Anabolic and Anti-Catabolic Therapy in OsteoporosisR01AR068332 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SANKAR, UMA · 2015 to 2019
$2.1M
NCATS NIH HHS UL1 TR002529NIAMS NIH HHS R01 AR068332NIAMS NIH HHS R01 AR074473NIAMS NIH HHS R01 AR076477NIAMS NIH HHS T32 AR065971NIH HHS AR065971NIH HHS R01AR068332NIH HHS R01AR076477NIH HHS UL1TR002529
6 · The paper itself

Abstract

Calcium/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) regulates bone remodeling through its effects on osteoblasts and osteoclasts. However, its role in osteocytes, the most abundant bone cell type and the master regulator of bone remodeling, remains unknown. Here we report that the conditional deletion of CaMKK2 from osteocytes using Dentine matrix protein 1 (

Indexed as

OsteoclastsOsteocytesAnimalsCalciumCalcium-Binding ProteinsCalcium-Calmodulin-Dependent Protein Kinase KinaseCulture Media, ConditionedFemaleMiceSex CharacteristicsCalciumCalcium-Binding ProteinsCalcium-Calmodulin-Dependent Protein Kinase KinasecalpastatinCamkk2 protein, mouseCulture Media, Conditionedbone remodelingCa2+/calmodulin (CaM)-dependent protein kinase kinase 2extracellular calpastatinosteoclastsosteocytes

Identifiers

PMID36902150
PMCPMC10003151
OpenAlexW4322743085

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read51
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.