Evidence map›Paper›PMID 36902088›Full record

ReviewInternational journal of molecular sciences2023

Advances in Ferritin Physiology and Possible Implications in Bacterial Infection.

Clemens M Gehrer, Anna-Maria Mitterstiller, Philipp Grubwieser, Esther G Meyron-Holtz, Günter Weiss, Manfred Nairz

Full text readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Cellular Landscape of Synovial Chondromatosis Synovium Revealed by Single-Cell RNA Sequencing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  8. Review
  9. Article
  10. Diagnostics: Markers of Body Iron Status.Advances in experimental medicine and biology · 2025
    Review
  11. Article
  12. Biomarkers associated with the diagnosis and prognosis ofFrontiers in cellular and infection microbiology · 2025
    Review
  13. Cellular Iron Homeostasis.Advances in experimental medicine and biology · 2025
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Frontiers in microbiology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Clemens M GehrerDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-9454-6375
Anna-Maria MitterstillerDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-9338-5135
Philipp GrubwieserDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-6233-8910
Esther G Meyron-HoltzLaboratory of Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel.
Günter WeissDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-0709-2158
Manfred NairzDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Funding

Austrian Science Fund FWF P 33062Christian Doppler Society W1253FWF Austrian Science Fund DOC 82 doc.fund; doctoral program MCBDFWF Austrian Science Fund FWF-Doctoral Programm HOROSFWF Austrian Science Fund P33062-BIsrael Science Foundation 515/2018
6 · The paper itself

Abstract

Due to its advantageous redox properties, iron plays an important role in the metabolism of nearly all life. However, these properties are not only a boon but also the bane of such life forms. Since labile iron results in the generation of reactive oxygen species by Fenton chemistry, iron is stored in a relatively safe form inside of ferritin. Despite the fact that the iron storage protein ferritin has been extensively researched, many of its physiological functions are hitherto unresolved. However, research regarding ferritin's functions is gaining momentum. For example, recent major discoveries on its secretion and distribution mechanisms have been made as well as the paradigm-changing finding of intracellular compartmentalization of ferritin via interaction with nuclear receptor coactivator 4 (NCOA4). In this review, we discuss established knowledge as well as these new findings and the implications they may have for host-pathogen interaction during bacterial infection.

Indexed as

Bacterial InfectionsFerritinsHumansIronNuclear Receptor CoactivatorsReactive Oxygen SpeciesFerritinsIronNCOA4 protein, humanNuclear Receptor CoactivatorsReactive Oxygen Speciescompartmentalizationexosomeferritinimmune metabolismironliquid-liquid phase separationmacrophagenutritional immunityregulationSalmonella Typhimurium

Identifiers

PMID36902088
PMCPMC10003477

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.