Evidence map›Paper›PMID 36902031›Full record

ArticleInternational journal of molecular sciences2023

Transcriptomic Analyses of Brains of RBM8A Conditional Knockout Mice at Different Developmental Stages Reveal Conserved Signaling Pathways Contributing to Neurodevelopmental Diseases.

Colleen McSweeney, Miranda Chen, Fengping Dong, Aswathy Sebastian, Derrick James Reynolds, Jennifer Mott, Zifei Pei, Jizhong Zou, Yongsheng Shi, Yingwei Mao

Open access · goldFull text read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. TAR syndrome causal genebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Colleen McSweeneyDepartment of Biology, Pennsylvania State University, University Park, PA 16802, USA.
Miranda ChenDepartment of Biology, Pennsylvania State University, University Park, PA 16802, USA.
Fengping DongDepartment of Biology, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0001-5688-4165
Aswathy SebastianDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Derrick James ReynoldsDepartment of Microbiology & Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA.
Jennifer MottDepartment of Biology, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-3506-6929
Zifei PeiDepartment of Biology, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0009-0004-6484-6547
Jizhong ZouSystems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, Rockville, MD 20892, USA.ORCID 0000-0003-1021-0549
Yongsheng ShiDepartment of Microbiology & Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA.
Yingwei MaoDepartment of Biology, Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0001-7339-1565
Pennsylvania State University · USUniversity of California, Irvine · USNational Heart Lung and Blood Institute · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
NHLBI iPSC Core FacilityZICHL006145 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ZOU, JIZHONG · 2012 to 2025
$23.3M
Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
Translational control in neurogenesis by ZNF804AR01MH122556 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI MAO, YINGWEI, SHI, YONGSHENG · 2020 to 2024
$1.7M
NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1 TR002014NIH HHS UL1TR002014 and 2UL1TR002014-05A1NIMH NIH HHS R01 MH122556
6 · The paper itself

Abstract

RNA-binding motif 8A (RBM8A) is a core component of the exon junction complex (EJC) that binds pre-mRNAs and regulates their splicing, transport, translation, and nonsense-mediated decay (NMD). Dysfunction in the core proteins has been linked to several detriments in brain development and neuropsychiatric diseases. To understand the functional role of

Indexed as

BrainTranscriptomeAnimalsMiceMice, KnockoutRNA-Binding ProteinsSignal TransductionRBM8A protein, mouseRNA-Binding Proteinsautismexon junction complexnonsense-mediated decayRBM8ARNAseqschizophrenia

Identifiers

PMID36902031
PMCPMC10003467
OpenAlexW4322501746

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read18
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.