ArticleInternational journal of molecular sciences2023
Low Dose of BPA Induces Liver Injury through Oxidative Stress, Inflammation and Apoptosis in Long-Evans Lactating Rats and Its Perinatal Effect on Female PND6 Offspring.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Chronic bisphenol A exposure at LOAEL induces hepatic metabolic remodeling associated with NAFLD-related pathways and hepatocarcinogenic susceptibility.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Vitamin C Alleviates BPA Embryotoxicity by Attenuating Oxidative Stress and DNA Damage-Mediated Apoptosis via Modulation of the ATM/Chk2/p53 Pathway.Journal of agricultural and food chemistry · 2026Article
- A Natural Monoterpene, Carvacrol, Mitigates Bisphenol A-Triggered Hepatorenal Oxidative Damage, Pro-Inflammatory Gene Expression, and Histopathological Alterations in Rats.Life (Basel, Switzerland) · 2026Article
- Trans sodium crocetinate protects against hepatotoxicity induced by bisphenol A in rats.Iranian journal of basic medical sciences · 2026Article
- Transgenerational reproductive risks of BPA: epigenetic mechanisms and biomarker applications. A critical review.Environmental epigenetics · 2026Review
- Berberine nanoemulsion attenuates bisphenol A-induced metabolic impairment through NF-κB signaling in the liver of rat.Toxicology reports · 2025Article
- Bisphenol A Alters the Expression of Genes Involved in Lipogenesis, Inflammation, and Oxidative Stress in the Liver of Adult Zebrafish.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Oxidative stress, apoptosis and proliferation in uterus of piglets fed by sow or formula after ex vivo endocrine compound exposure.Scientific reports · 2025Article
- Associations of exposure to bisphenol-A or parabens with markers of liver injury/function among US adults in NHANES 2011-2016.Journal of exposure science & environmental epidemiology · 2025Article
- Article
- DINCH Exposure Triggers Inflammatory, Oxidative, and Apoptotic Pathways in the Liver of Long-Evans Lactating Rats and Their Offspring.International journal of molecular sciences · 2024Article
- Methanolic extract of wheatgrass (3 Biotech · 2024Article
- Endocrine-Disrupting Chemicals: A Looming Threat to Current and Future Generations.International journal of molecular sciences · 2024Article
- Liver and Pancreatic Toxicity of Endocrine-Disruptive Chemicals: Focus on Mitochondrial Dysfunction and Oxidative Stress.International journal of molecular sciences · 2024Review
- Article
- The Immunoregulatory and Regenerative Potential of Activated Human Stem Cell Secretome Mitigates Acute-on-Chronic Liver Failure in a Rat Model.International journal of molecular sciences · 2024Article
- Bombesin-like receptor 3 expression induced by bisphenol A is likely associated with reduced cell proliferation by inhibiting DNA synthesis and inducing inflammation in liver cells.Molecular biology reports · 2024Article
- Activation of NLRP3 Inflammasome in Liver of Long Evans Lactating Rats and Its Perinatal Effects in the Offspring after Bisphenol F Exposure.International journal of molecular sciences · 2023Article
- Oxidative stress increases in liver of lactating rats after BPF-low-dose exposure: perinatal effects in the offspring.Scientific reports · 2023Article
- A Silent Threat: Exploring the Impact of Endocrine Disruption on Human Health.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Bisphenol A (BPA) is a phenolic compound used in plastics elaboration for food protection or packaging. BPA-monomers can be released into the food chain, resulting in continuous and ubiquitous low-dose human exposure. This exposure during prenatal development is especially critical and could lead to alterations in ontogeny of tissues increasing the risk of developing diseases in adulthood. The aim was to evaluate whether BPA administration (0.036 mg/kg b.w./day and 3.42 mg/kg b.w./day) to pregnant rats could induce liver injury by generating oxidative stress, inflammation and apoptosis, and whether these effects may be observed in female postnatal day-6 (PND6) offspring. Antioxidant enzymes (CAT, SOD, GR, GPx and GST), glutathione system (GSH/GSSG) and lipid-DNA damage markers (MDA, LPO, NO, 8-OHdG) were measured using colorimetric methods. Inducers of oxidative stress (HO-1d, iNOS, eNOS), inflammation (IL-1β) and apoptosis (AIF, BAX, Bcl-2 and BCL-XL) were measured by qRT-PCR and Western blotting in liver of lactating dams and offspring. Hepatic serum markers and histology were performed. Low dose of BPA caused liver injury in lactating dams and had a perinatal effect in female PND6 offspring by increasing oxidative stress levels, triggering an inflammatory response and apoptosis pathways in the organ responsible for detoxification of this endocrine disruptor.
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Registered trials
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