Evidence map›Paper›PMID 36901993›Full record

ReviewInternational journal of molecular sciences2023

Focus on the Use of Resveratrol in Bladder Cancer.

Alessandro Zucchi, Francesco Claps, Antonio Luigi Pastore, Alessandro Perotti, Andrea Biagini, Luana Sallicandro, Rosaria Gentile, Concetta Caglioti, Federico Palazzetti, Bernard Fioretti

Full text readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Electro-Metabolic Coupling of Cumulus-Oocyte Complex.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Hypolipidemic and Anti-Inflammatory Effects ofInternational journal of molecular sciences · 2023
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandro ZucchiDepartment of Translational Research and New Technologies, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-2252-4297
Francesco ClapsDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 56126 Trieste, Italy.ORCID 0000-0003-2812-5553
Antonio Luigi PastoreDepartment of Urology, ICOT Latina, Polo Pontino, La Sapienza University of Rome, 04100 Latina, Italy.
Alessandro PerottiDepartment of Translational Research and New Technologies, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4692-6824
Andrea BiaginiDepartment of Medicine and Surgery, Perugia Medical School, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.ORCID 0000-0002-7937-2784
Luana SallicandroDepartment of Medicine and Surgery, Perugia Medical School, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.
Rosaria GentileDepartment of Chemistry, Biology and Biotechnologies, University of Perugia, Via dell'Elce di Sotto 8, 06132 Perugia, Italy.
Concetta CagliotiDepartment of Medicine and Surgery, Perugia Medical School, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.
Federico PalazzettiDepartment of Chemistry, Biology and Biotechnologies, University of Perugia, Via dell'Elce di Sotto 8, 06132 Perugia, Italy.ORCID 0000-0002-1361-0524
Bernard FiorettiDepartment of Chemistry, Biology and Biotechnologies, University of Perugia, Via dell'Elce di Sotto 8, 06132 Perugia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer is the most common tumor of the urinary system, with a high incidence in the male population. Surgery and intravesical instillations can eradicate it, although recurrences are very common, with possible progression. For this reason, adjuvant therapy should be considered in all patients. Resveratrol displays a biphasic dose response both in vitro and in vivo (intravesical application) with an antiproliferative effect at high concentrations and antiangiogenic action in vivo (intraperitoneal application) at a low concentration, suggesting a potential role for it in clinical management as an adjuvant to conventional therapy. In this review, we examine the standard therapeutical approach to bladder cancer and the preclinical studies that have investigated resveratrol in xenotransplantation models of bladder cancer. Molecular signals are also discussed, with a particular focus on the STAT3 pathway and angiogenic growth factor modulation.

Indexed as

Urinary Bladder NeoplasmsAdministration, IntravesicalCombined Modality TherapyHumansMaleResveratrolResveratrolangiogenesisapoptosisbladder cancerproliferationresveratrol

Identifiers

PMID36901993
PMCPMC10003096

What OpenQuestion holds

Textfull text, public
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.