Evidence map›Paper›PMID 36901879›Full record

ArticleInternational journal of molecular sciences2023

ZnO Tetrapods for Label-Free Optical Biosensing: Physicochemical Characterization and Functionalization Strategies.

Monica Terracciano, Simas Račkauskas, Andrea Patrizia Falanga, Sara Martino, Giovanna Chianese, Francesca Greco, Gennaro Piccialli, Guido Viscardi, Luca De Stefano, Giorgia Oliviero and 2 more

Full text read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Monica TerraccianoDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID 0000-0001-6367-2419
Simas RačkauskasInstitute of Materials Science, Kaunas University of Technology, 51423 Kaunas, Lithuania.ORCID 0000-0002-8964-5299
Andrea Patrizia FalangaDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
Sara MartinoUnit of Naples, National Research Council, Institute of Applied Sciences and Intelligent Systems, Via Pietro Castellino 111, 80131 Naples, Italy.
Giovanna ChianeseUnit of Naples, National Research Council, Institute of Applied Sciences and Intelligent Systems, Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0001-9037-5102
Francesca GrecoDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID 0000-0003-4217-7990
Gennaro PiccialliDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-1313-2091
Guido ViscardiDepartment of Chemistry, NIS Interdepartmental Centre, University of Turin, Via Pietro Giuria 7, 10125 Turin, Italy.ORCID 0000-0002-9387-2849
Luca De StefanoUnit of Naples, National Research Council, Institute of Applied Sciences and Intelligent Systems, Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0002-9442-4175
Giorgia OlivieroDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.ORCID 0000-0003-0765-2127
Nicola BorboneDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID 0000-0003-0216-9814
Ilaria ReaUnit of Naples, National Research Council, Institute of Applied Sciences and Intelligent Systems, Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0003-0568-9911

Funding

Governo Italiano PNRR MUR-M4C2 - Investimento 1.4- CUP UNINA: E63C22000940007
6 · The paper itself

Abstract

In this study, we fabricated three different ZnO tetrapodal nanostructures (ZnO-Ts) by a combustion process and studied their physicochemical properties by different techniques to evaluate their potentiality for label-free biosensing purposes. Then, we explored the chemical reactivity of ZnO-Ts by quantifying the available functional hydroxyl groups (-OH) on the transducer surface necessary for biosensor development. The best ZnO-T sample was chemically modified and bioconjugated with biotin as a model bioprobe by a multi-step procedure based on silanization and carbodiimide chemistry. The results demonstrated that the ZnO-Ts could be easily and efficiently biomodified, and sensing experiments based on the streptavidin target detection confirmed these structures' suitability for biosensing applications.

Indexed as

Biosensing TechniquesNanostructuresZinc OxideBiotinBiotinZinc Oxidelabel-free detectionquantum yieldsurface characterizationsurface functionalizationzinc oxide nanostructure

Identifiers

PMID36901879
PMCPMC10002590

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.