Evidence map›Paper›PMID 36901860›Full record

ArticleInternational journal of molecular sciences2023

Influence of Genetic Variations in miRNA and Genes Encoding Proteins in the miRNA Synthesis Complex on Toxicity of the Treatment of Pediatric B-Cell ALL in the Brazilian Amazon.

Elisa da Silva Menezes, Francisco Cezar Aquino de Moraes, Amanda de Nazaré Cohen-Paes, Alayde Vieira Wanderley, Esdras Edgar Batista Pereira, Lucas Favacho Pastana, Antônio André Conde Modesto, Paulo Pimentel de Assumpção, Rommel Mario Rodríguez Burbano, Sidney Emanuel Batista Dos Santos and 2 more

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In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Medical sciences (Basel, Switzerland) · 2025
    Review
  4. Association ofCurrent issues in molecular biology · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elisa da Silva MenezesOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Francisco Cezar Aquino de MoraesOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Amanda de Nazaré Cohen-PaesOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.ORCID 0000-0003-3548-292X
Alayde Vieira WanderleyOtávio Lobo Children's Cancer Hospital, Belém 66063-005, PA, Brazil.
Esdras Edgar Batista PereiraOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.ORCID 0000-0003-4830-4233
Lucas Favacho PastanaOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Antônio André Conde ModestoOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Paulo Pimentel de AssumpçãoOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Rommel Mario Rodríguez BurbanoOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Sidney Emanuel Batista Dos SantosOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Ney Pereira Carneiro Dos SantosOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Marianne Rodrigues FernandesOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.ORCID 0000-0002-1396-3442

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in the world. Single nucleotide variants (SNVs) in miRNA and genes encoding proteins of the miRNA synthesis complex (SC) may affect the processing of drugs used in the treatment of ALL, resulting in treatment-related toxicities (TRTs). We investigated the role of 25 SNVs in microRNA genes and genes encoding proteins of the miRNA SC, in 77 patients treated for ALL-B from the Brazilian Amazon. The 25 SNVs were investigated using the TaqMan

Indexed as

MicroRNAsPrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrecursor Cell Lymphoblastic Leukemia-LymphomaBrazilChildHumansPolymorphism, Single NucleotideMicroRNAsMIRN149 microRNA, humanMIRN605 microRNA, humanacute lymphoblastic leukemiaancestrymiRNASNVstoxicity

Identifiers

PMID36901860
PMCPMC10003057

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read25
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.