Evidence map›Paper›PMID 36901844›Full record

ArticleInternational journal of molecular sciences2023

Application of Nicotinamide to Culture Medium Improves the Efficiency of Genome Editing in Hexaploid Wheat.

Wanxin Wang, Peipei Huang, Wenshuang Dai, Huali Tang, Yuliang Qiu, Yanan Chang, Zhiyang Han, Xi Li, Lipu Du, Xingguo Ye and 2 more

Full text read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. CRISPR-Based Editing of thePlants (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wanxin WangInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Peipei HuangInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Wenshuang DaiInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Huali TangInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Yuliang QiuInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Yanan ChangInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Zhiyang HanInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Xi LiInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Lipu DuInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Xingguo YeInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.ORCID 0000-0002-6616-2753
Cheng ZouNational Key Facility of Crop Resources and Genetic Improvement, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Ke WangInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.ORCID 0000-0001-6776-4935

Funding

Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences S2022ZD03National Natural Science Foundation of China 31871710National Natural Science Foundation of China 31971946the Agricultural Science and Technology Innovation Program of the Chinese Academy of Ag-ricultural Sciences 2060302-2-19
6 · The paper itself

Abstract

Histone acetylation is the earliest and most well-characterized of post-translation modifications. It is mediated by histone acetyltransferases (HAT) and histone deacetylases (HDAC). Histone acetylation could change the chromatin structure and status and further regulate gene transcription. In this study, nicotinamide, a histone deacetylase inhibitor (HDACi), was used to enhance the efficiency of gene editing in wheat. Transgenic immature and mature wheat embryos harboring a non-mutated

Indexed as

Gene EditingTriticumCRISPR-Cas SystemsHistonesMutationHistonesbase editingCRISPR/Cas9editing efficiencyhistone deacetylase inhibitorsnicotinamidewheat

Identifiers

PMID36901844
PMCPMC10002385

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.