Evidence map›Paper›PMID 36901833›Full record

ArticleInternational journal of molecular sciences2023

Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia.

Patricia Reboucas, Carine Fillebeen, Amy Botta, Riley Cleverdon, Alexandra P Steele, Vincent Richard, René P Zahedi, Christoph H Borchers, Yan Burelle, Thomas J Hawke and 2 more

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Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Patricia ReboucasDepartment of Biology, York University, Toronto, ON M3J 1P3, Canada.
Carine FillebeenLady Davis Institute for Medical Research, Department of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.
Amy BottaDepartment of Biology, York University, Toronto, ON M3J 1P3, Canada.
Riley CleverdonDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.ORCID 0000-0002-1074-3647
Alexandra P SteeleDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Vincent RichardLady Davis Institute for Medical Research, Department of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.ORCID 0000-0001-7224-1290
René P ZahediLady Davis Institute for Medical Research, Department of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.
Christoph H BorchersLady Davis Institute for Medical Research, Department of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.ORCID 0000-0003-2394-6512
Yan BurelleDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Thomas J HawkeDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Kostas PantopoulosLady Davis Institute for Medical Research, Department of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.ORCID 0000-0002-2305-0057
Gary SweeneyDepartment of Biology, York University, Toronto, ON M3J 1P3, Canada.

Funding

Thalassemia Foundation of Canada GS
6 · The paper itself

Abstract

Although metabolic complications are common in thalassemia patients, there is still an unmet need to better understand underlying mechanisms. We used unbiased global proteomics to reveal molecular differences between the th

Indexed as

beta-ThalassemiaAnimalsMiceMitochondriaMuscle, SkeletalOxidation-ReductionProteomicsironmitochondriaproteomicsskeletal musclethalassemia

Identifiers

PMID36901833
PMCPMC10002226

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.