Evidence map›Paper›PMID 36901790›Full record

ArticleInternational journal of molecular sciences2023

Purification of PaTx-II from the Venom of the Australian King Brown Snake and Characterization of Its Antimicrobial and Wound Healing Activities.

Ramar Perumal Samy, Stephen P Mackessy, Alagarmalai Jeyasankar, Mano Ranjana Ponraj, Octavio Luiz Franco, Matthew A Cooper, Matheswaran Kandasamy, Tapan Kumar Mohanta, Jebasingh Bhagavathsingh, Sakthivel Vaiyapuri

Full text read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Toxins turned into medicines: A systematic review of peptide animal-derived venom in wound treatments.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026
    Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ramar Perumal SamyDepartment of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, NUHS, MD10, 4 Medical Drive, Singapore 117594, Singapore.
Stephen P MackessySchool of Biological Sciences, Campus Box 92, College of Natural and Health Sciences, University of Northern Colorado, 501 20th St., Greeley, CO 80639, USA.ORCID 0000-0003-4515-2545
Alagarmalai JeyasankarDepartment of Zoology, Government Arts College (Autonomous), Coimbatore 641018, Tamil Nadu, India.
Mano Ranjana PonrajMedicinal Organic Chemistry Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamil Nadu, India.
Octavio Luiz FrancoCentro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, UCB, Brasilia 71966-700, DF, Brazil.ORCID 0000-0001-9546-0525
Matthew A CooperInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0003-3147-3460
Matheswaran KandasamyRadcliffee Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Tapan Kumar MohantaNatural and Medical Sciences Research Center, University of Nizwa, Nizwa 611, Oman.ORCID 0000-0002-3196-7746
Jebasingh BhagavathsinghMedicinal Organic Chemistry Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamil Nadu, India.ORCID 0000-0003-3405-6208
Sakthivel VaiyapuriSchool of Pharmacy, University of Reading, Reading RG6 6UB, UK.ORCID 0000-0002-6006-6517

Funding

Medical Research Council MR/W019353/1
6 · The paper itself

Abstract

Infections caused by multi-drug-resistant (MDR) bacteria are a global threat to human health. As venoms are the source of biochemically diverse bioactive proteins and peptides, we investigated the antimicrobial activity and murine skin infection model-based wound healing efficacy of a 13 kDa protein. The active component PaTx-II was isolated from the venom of

Indexed as

Anti-Infective AgentsCnidarian VenomsColubridaeAnimalsAustraliaCollagenCytokinesHumansMammalsMicePeptidesStaphylococcus aureusWound HealingAnti-Infective AgentsCnidarian VenomsCollagenCytokinesparasicyonis toxinPeptidesantibioticantimicrobialAustralian king brown snake venomfusidic acid ointmentPaTx-IIPseudechis australiswound

Identifiers

PMID36901790
PMCPMC10002107

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read87
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.