ReviewInternational journal of molecular sciences2023
Outdoor Air Pollution and Childhood Respiratory Disease: The Role of Oxidative Stress.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Air pollution and hospitalization risk in infants with bronchiolitis: A systematic review and meta-analysis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Pooled it
- Cardiopulmonary and Immune Effects of Environmental Particulate Exposures.Physiology (Bethesda, Md.) · 2026Review
- Size-Resolved PMToxics · 2026Article
- From ideal respiratory health to chronic lung disease: indicators of impaired respiratory health.Expert review of respiratory medicine · 2026Review
- Integrated spatial analysis and Gaussian dispersion modelling of airborne particulate matter from rice processing mill hubs in rural Bangladesh and associated public health risks.Environmental science and pollution research international · 2026Article
- Air pollution and the risk of bronchiolitis-related hospital admission in a birth cohort of over 400,000 children born in London.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Oxidative Stress in Asthma Pathogenesis: Mechanistic Insights and Emerging Biomarker Signatures.International journal of molecular sciences · 2026Review
- Ambient PMBMC public health · 2026Article
- Niacin Supplementation Alleviates TCIPP-Induced Lung Injury via Inhibition of the NF-κB Signaling Pathway.Antioxidants (Basel, Switzerland) · 2026Article
- Extreme Cold Events and Pediatric Asthma Outpatient Visits: The Modifying Role of Ambient Carbon Monoxide and Sulfur Dioxide.Journal of asthma and allergy · 2026Article
- Development of the Respiratory System During Adolescence.Advances in experimental medicine and biology · 2026Review
- Environmental and socioeconomic influences on childhood asthma and pneumonia: burden and healthcare utilization in a population-based cohort study.Frontiers in medicine · 2026Article
- Short-term traffic-related gaseous pollutant exposure is associated with childhood bronchopneumonia hospitalization: a 10-year time-series study from Guangzhou, China.Frontiers in public health · 2026Article
- Air pollution exposure and the burden of pediatric upper respiratory tract infections in emergency departments: a retrospective time-series study.European journal of pediatrics · 2025Article
- Respiratory Emergencies in Pediatrics: Associations in Redlining, Air Quality and Traffic Regulation The REPARATION Study during COVID-19.Journal of racial and ethnic health disparities · 2025Article
- Bayesian joint spatiotemporal modelling of primary infection and reinfection of HFMD at county level in Jiangsu, China, 2009-2023.BMC public health · 2025Article
- A Study Protocol to Assess the Association Between Ambient Air Pollution and Asthma and Other Respiratory Health Outcomes Amongst Children Below 5 Years of Age in Alexandra Township's Early Childhood Development Centers, Johannesburg.Methods and protocols · 2025Article
- Health risk and disease burden of daily hospitalizations for vaginitis due to air pollution: evidence from a heavily-polluted-city in China.BMC public health · 2025Article
- The first 1000 days: the price of inequalities in high and middle-income countries.Pediatric research · 2025Review
- Long-term PMERJ open research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The leading mechanisms through which air pollutants exert their damaging effects are the promotion of oxidative stress, the induction of an inflammatory response, and the deregulation of the immune system by reducing its ability to limit infectious agents' spreading. This influence starts in the prenatal age and continues during childhood, the most susceptible period of life, due to a lower efficiency of oxidative damage detoxification, a higher metabolic and breathing rate, and enhanced oxygen consumption per unit of body mass. Air pollution is involved in acute disorders like asthma exacerbations and upper and lower respiratory infections, including bronchiolitis, tuberculosis, and pneumoniae. Pollutants can also contribute to the onset of chronic asthma, and they can lead to a deficit in lung function and growth, long-term respiratory damage, and eventually chronic respiratory illness. Air pollution abatement policies, applied in the last decades, are contributing to mitigating air quality issues, but more efforts should be encouraged to improve acute childhood respiratory disease with possible positive long-term effects on lung function. This narrative review aims to summarize the most recent studies on the links between air pollution and childhood respiratory illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.